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Determinants of Hypovitaminosis D in Pregnant Women and Their Newborns in a Sunny Region Publisher



Kelishadi R1 ; Sharifighazvini F1 ; Poursafa P2 ; Mehrabian F3 ; Farajian S4 ; Yousefy H2 ; Movahedian M5 ; Sharifighazvini S6
Authors
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Authors Affiliations
  1. 1. Pediatrics Department, Faculty of Medicine and Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan 81676-36954, Iran
  2. 2. Environmental Protection Department, Environment Research Center, Isfahan University of Medical Sciences, Isfahan 81676-36954, Iran
  3. 3. Obstetrics and Gynecology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan 81676-36954, Iran
  4. 4. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81676-36954, Iran
  5. 5. Department of English Linguistics, University of Isfahan, Isfahan 81676-36954, Iran
  6. 6. Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran

Source: International Journal of Endocrinology Published:2013


Abstract

This study aims to assess the factors associated with 25-hydroxy vitamin D (25(OH)D) levels in pregnant women and their newborns in a sunny region. Materials and Methods. This cross-sectional study was conducted in 2012 in Isfahan, Iran. It comprised 100 nulliparous singleton pregnant women, selected by random cluster sampling. Laboratory tests were assessed before delivery in mothers and after delivery in their infants' umbilical cord blood. The P for trend of variables was assessed across the air quality index (AQI) quartiles. The associations of AQI and 25(OH)D were assessed by multiple linear regression after adjustment for age, body mass index, and dietary intake. Results. Sera of 98 mothers and an equal number of newborns were analyzed. The median (interquartile range, IQR) of serum 25(OH)D of mothers and neonates was 15.1(12.6, 18.2) ng/mL in mothers and 15.7(12.0, 18.1) ng/mL in neonates, respectively. AQI had an inverse association with serum 25(OH)D (Beta = -0.58, P = 0.04). The corresponding figure was also inverse and significant for newborns (Beta (SE)= -0.51(0.04), P = 0.01). Conclusion. The independent inverse association of 25(OH)D with air quality can explain the high prevalence of hypovitaminosis D in pregnant women living in this sunny region. © 2013 Roya Kelishadi et al.
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