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The Potential of Targeting Autophagy-Related Non-Coding Rnas in the Treatment of Alzheimer’S and Parkinson’S Diseases Publisher Pubmed



Talebi Taheri A1, 2 ; Golshadi Z3 ; Zare H4 ; Alinaghipour A5 ; Faghihi Z6 ; Dadgostar E7, 8 ; Tamtaji Z9 ; Aschner M10 ; Mirzaei H11 ; Tamtaji OR6, 12 ; Nabavizadeh F6, 12
Authors
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Authors Affiliations
  1. 1. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  4. 4. University of Szeged, Szeged, Hungary
  5. 5. School of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran
  6. 6. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  10. 10. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  11. 11. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  12. 12. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular and Molecular Neurobiology Published:2024


Abstract

Clearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases. Dysregulation of these non-coding RNAs has been associated with inhibition or stimulation of autophagy. Decreased miR-124 led to decreased/increased autophagy in experimental model of Alzheimer and Parkinson diseases. Increased BACE1-AS showed enhanced autophagy in Alzheimer disease by targeting miR-214-3p, Beclin-1, LC3-I/LC3-II, p62, and ATG5. A significant increase in NEAT1led to stimulated autophagy in experimental model of PD by targeting PINK1, LC3-I, LC3-II, p62 and miR-374c-5p. In addition, increased BDNF-AS and SNHG1 decreased autophagy in MPTP-induced PD by targeting miR-125b-5p and miR-221/222, respectively. The upregulation of circNF1-419 and circSAMD4A resulted in an increased autophagy by regulating Dynamin-1 and miR-29c 3p, respectively. A detailed discussion of miRNAs, circRNAs, and lncRNAs in relation to their autophagy-related signaling pathways is presented in this study. Graphical Abstract: Autophagy-related non-coding RNAs in neurodegenerative diseases. (Figure presented.). © The Author(s) 2024.
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