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Evaluating and Modeling the Mechanical Properties of the Prepared Plga/Nano-Bcp Composite Scaffolds for Bone Tissue Engineering Publisher



Ehrahimianhosseinabadi M1, 2 ; Ashrafizadeh F1 ; Etemadifar M3 ; Venkatraman SS4
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran
  2. 2. Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
  3. 3. Orthopedic Departments, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
  4. 4. Materials Science and Engineering School, Nanyang Technological University, 637819, Singapore

Source: Journal of Materials Science and Technology Published:2011


Abstract

In this paper, preparation of nano-biphasic calcium phosphate (nBCP), mechanical behavior and load-bearing of poly (lactide-co-glycolide) (PLGA) and PLGA/nBCP are presented. The nBCP with composition of 63/37 (w/w) HA/β-TCP (hydroxyapatite/β-tricalcium phosphate) was produced by heating of bovine bone at 700°C. Composite scaffolds were made by using PLGA matrix and 10-50 wt% nBCP powders as reinforcement material. All scaffolds were prepared by thermally induced solid-liquid phase separation (TIPS) at -60°C under 4 Pa (0.04 mbar) vacuum. The results of elastic modulus testing were adjusted with Ishai-Cohen and Narkis models for rigid polymeric matrix and compared to each other. PLGA/nBCP scaffolds with 30 wt% nBCP showed the highest value of yield strength among the scaffolds. In addition, it was found that by increasing the nBCP in scaffolds to 50 wt%, the modulus of elasticity was highly enhanced. However, the optimum value of yield strength was obtained at 30 wt% nBCP, and the agglomeration of reinforcing particles at higher percentages caused a reduction in yield strength. It is clear that the elastic modulus of matrix has the significant role in elastic modulus of scaffolds, as also the size of the filler particles in the matrix. © 2011 The Chinese Society for Metals.
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