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Morphology and Degradation of Poly (3-Hydroxybutyrate)/ Nano-Hydroxyapatite Scaffold Used in Tissue Engineering



Radmehr M1 ; Karbasi S2 ; Sadeghi M1 ; Khorasani SN1 ; Saadat A3
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Authors Affiliations
  1. 1. Department of Chemical Engineering, School of Chemical Engineering, Isfahan University of Technology, Isfahan, Iran
  2. 2. Department of Medical Physics and Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: Nanocomposites of biodegradable polymers and bioactive ceramics have high biocompatible and mechanical properties and are thus of high importance in bone tissue engineering. Among these nanocomposites, poly (3-hydroxybutyrate)/nano-hydroxyapatite (PHB/nHA) has favorable porosity. Methods: Nanocomposite scaffolds of PHB/nHA were prepared via solvent-casting and particulate leaching technique. NHA constituted 0-10% of weight of polymers. The porosity of the samples was measured by diffusion method. Scanning electron microscopy (SEM) was used to evaluate the morphology of prepared scaffolds and size of nano-particles in the polymer matrix. Distribution of nHA in scaffold was investigated by energy dispersive X-ray (EDX). Degradation of scaffolds was studied by SEM, Fourier transform infrared (FTIR) spectroscopy, and weighting samples before and after degradation in phosphatebuffered saline (PBS) solution. Findings: Porosity percentage was not decreased by increasing nHA content. Size of HA particles on wall of scaffold porosity was in nano-scale and distribution of nano particles in polymer matrix was uniform. Type of PHB/nHA scaffold degradation in PBS solution was bulk degradation. Conclusion: Prepared scaffolds had good interconnectivity. Size and percentage of porosity was acceptable for cell growth, attachment, and seepage in tissue engineering. Therefore, these new PHB/nHA nanocomposite scaffolds may serve as a 3D substrate in tissue engineering. © 2012, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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