Physical and Mechanical Properties of a Poly-3-Hydroxybutyratecoated Nanocrystalline Hydroxyapatite Scaffold for Bone Tissue Engineering Publisher



Foroughi MR¹ ; Karbasi S² ; Ebrahimikahrizsangi R¹ Show Affiliations
Source: Journal of Porous Materials Published:2012

Abstract

A major challenge for tissue engineers is the design of scaffolds with appropriate physical and mechanical properties. The present research discusses the formation of ceramic scaffolding in tissue engineering. Hydroxyapatite (HAp) powder was made from bovine bone by thermal treatment at 900 °C; 40, 50 and 60%wt porous HAp was then produced using the polyurethane sponge replication method. Scaffolds were coated with poly-3-hydroxybutyrate (P3HB) for 30 s and 1 min in order to increase the scaffold's mechanical properties. XRD, SEM and FT-IR were used to study phase structure, morphology and agent groups, respectively. In XRD and FT-IR data, established hydrogen bands between polymer and ceramic matrix confirm that the scaffold is formed as a composite. The scaffold obtained with 50%wt HAp and a 30 s coating was 90% porous, with an average diameter of 100-400 lm, and demonstrated a compressive strength and modulus of 1.46 and 21.27 MPa, respectively. Based on these results, this scaffold is optimised for the aforementioned properties and can be utilised in bone tissue engineering. © Springer Science+Business Media, LLC 2011.