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Impact of Analgesics on the Risk of Ovarian Cancer; a Systematic Review and Meta-Analysis of Cohort and Case-Control Studies Publisher



Sadeghi J1 ; Bazzazi S2 ; Fattahi F3 ; Mousavi MA2 ; Tajbakhsh A4 ; Rassouli S5 ; Sangi S6 ; Ghezelbash M7 ; Ghorbani A8
Authors
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Authors Affiliations
  1. 1. Be’sat Hospital, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
  2. 2. Department of Gynecology and Obstetrics, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Emergency Medicine, School of Medicine, Milad Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Anesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gynecology and Obstetrics, Imam Khomeini Hospital, School of Medicine, Sari University of Medical Sciences, Sari, Iran
  6. 6. Department of Anesthesia Technology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Hematology-Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Immunopathologia Persa Published:2025


Abstract

Introduction: Ovarian cancer is the sixth leading cancer-related mortality cause in women worldwide. Analgesics may hinder the occurrence of ovarian cancer through inflammation relief. The present study seeks to examine the relationship between analgesic consumption and ovarian cancer risk through a systematic review and meta-analysis. Materials and Methods: PubMed, Scopus, Web of Science, Cochrane databases, and Google Scholar search engines were searched for works published by May 2023 using standard keywords to collect the required data sources. Acquired data were then analyzed in STATA version14, considering a significance level of P < 0.05 in statistical tests. Results: The present meta-analysis comprised 21 studies (14 case-control and 7 cohort studies) performed on 53,755 subjects. Results indicated that taking aspirin reduced the risk of ovarian cancer by 8% (OR: 0.92; 95% CI: 0.87, 0.98), whereas other non-aspirin NSAIDs (non-steroidal anti-inflammatory drugs) did not significantly affect the ovarian cancer risk (OR: 0.91; 95% CI: 0.81, 1.02). Similar results were observed in the case of ibuprofen and acetaminophen, with non-significant relationships between the risk of ovarian cancer and with the consumption of both acetaminophen (OR: 0.95; 95% CI: 0.84, 1.08) and ibuprofen (OR: 0.76; 95% CI: 0.50, 1.14). Furthermore, the duration of analgesic consumption was not significantly linked to the risk of ovarian cancer in the case of all studied drugs. Conclusion: Among aspirin, ibuprofen, acetaminophen, and non-aspirin NSAIDs, only aspirin was found to reduce the risk of ovarian cancer in women while the other studied drugs did not influence the studied risk. However, further research is recommended to confirm the results. © 2025 The Author(s); Published by Nickan Research Institute.
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