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Microrna-196A As a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma Publisher Pubmed



Fendereski M1 ; Zia MF2 ; Shafiee M3 ; Safari F1 ; Saneie MH4 ; Tavassoli M1
Authors

Source: Cancer Investigation Published:2017


Abstract

We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p =.002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC. In addition, molecular pathway enrichment analysis of microRNA (miR)-196a determined focal adhesion, spliceosome and p53 signaling pathways as the most relevant pathways with miR-196a targetome. © 2017 Taylor & Francis Group, LLC.
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