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The Salivary Exosomal Microrna As a Potential Biomarker in Patients With Periodontitis and Oral Cancers Publisher Pubmed



Safari Z1 ; Firouzi A2 ; Rezaeikalantari N1 ; Mohammadi S3 ; Ranjbar N4 ; Shahpori H5 ; Khaleghi P6 ; Bagherianlemraski M7 ; Zandi S8 ; Rafieyan S9
Authors
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Authors Affiliations
  1. 1. Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Dentistry, Khorasgan University of Medical Sciences, Isfahan, Iran
  3. 3. School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Faculty of Dentistry, Sanandaj University of Medical Sciences, Sanandaj, Iran
  6. 6. Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Faculty of Dentistry, Arak University of Medical Sciences, Arak, Iran
  9. 9. Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Chemical Biology and Drug Design Published:2023


Abstract

Periodontitis and oral cancers are the most common oral diseases in the human population. The early diagnosis of oral diseases allows the efficient therapy of the patient. During oral diseases, resident cells in the affected tissue secrete exosomal microRNAs (miRNAs) into saliva. As these miRNAs have a crucial role in the pathogenesis of oral diseases, they have been suggested as non-invasive and validated biomarkers in predicting periodontitis severity and cancer progression. Several attempts have been performed to evaluate the expression of salivary exosomal miRNAs in patients with periodontitis and oral cancers. Some miRNAs are differentially expressed in the saliva of the affected patients when compared to healthy individuals. These miRNAs are reviewed in this narrative review. Collectively, it seems that salivary exosomal microRNAs could be used as a diagnostic biomarker in oral diseases. However, further studies are required to validate them. © 2022 John Wiley & Sons Ltd.
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