Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations

Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations Publisher Pubmed

Carinci F¹ ; Palmieri A² ; Scapoli L² ; Cura F² ; Borelli F³ ; Morselli PG^{2, 4} ; Nouri N⁵ ; Abdali H⁶ ; Gianni AB^{7, 8} ; Russillo A^{7, 8} ; Docimo R⁹ ; Martinelli M²

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1. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
2. Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
3. Plastic and Reconstructive Surgery Unit, Maugeri Clinical Scientific Institutes, Pavia, Italy
4. Plastic Surgery Unit, Sant’Orsola Malpighi University Hospital, Bologna, Italy
5. Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
6. Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
7. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
8. Maxillofacial and Dental Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
9. Department of Clinical Sciences and Translational Medicine, University of Tor Vergata, Rome, Italy

Source: International Journal of Immunopathology and Pharmacology Published:2019

Abstract

Periconceptional folic acid supplementation can reduce the risk of inborn malformations, including orofacial clefts. Polymorphisms of MTHFR, TCN2, and CBS folate-related genes seem to modulate the risk of cleft lip with or without cleft palate (CL/P) in some populations. CL/P and cleft palate only (CPO) are different malformations that share several features and possibly etiological causes. In the present investigation, we conducted a family-based, candidate gene association study of non-syndromic CPO. Three single nucleotide polymorphisms, namely, rs1801133 of MTHFR, rs1801198 of TCN2, and rs4920037 of CBS, were investigated in a sample that included 129 Italian and 65 Asian families. No evidence of association between the three genotyped polymorphisms and CPO was found in the Italian and Asian cases, indeed the transmission disequilibrium test did not detect any asymmetry of transmission of alleles. This investigation, although with some limitation, further supports that CL/P and CPO diverge in their genetic background. © The Author(s) 2019.

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Style	Citing Format
MLA	Carinci F, et al.. "Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations." International Journal of Immunopathology and Pharmacology, vol. 33, no. , 2019, pp. -.
APA	Carinci F, Palmieri A, Scapoli L, Cura F, Borelli F, Morselli PG, Nouri N, Abdali H, Gianni AB, Russillo A, Docimo R, Martinelli M (2019). Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations. International Journal of Immunopathology and Pharmacology, 33(), -.
Chicago	Carinci F, Palmieri A, Scapoli L, Cura F, Borelli F, Morselli PG, Nouri N, et al.. "Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations." International Journal of Immunopathology and Pharmacology 33, no. (2019): -.
Harvard	Carinci F et al. (2019) 'Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations', International Journal of Immunopathology and Pharmacology, 33(), pp. -.
Vancouver	Carinci F, Palmieri A, Scapoli L, Cura F, Borelli F, Morselli PG, et al.. Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations. International Journal of Immunopathology and Pharmacology. 2019;33():-.
BibTex	@article{ author = {Carinci F and Palmieri A and Scapoli L and Cura F and Borelli F and Morselli PG and Nouri N and Abdali H and Gianni AB and Russillo A and Docimo R and Martinelli M}, title = {Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations}, journal = {International Journal of Immunopathology and Pharmacology}, volume = {33}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Carinci F AU - Palmieri A AU - Scapoli L AU - Cura F AU - Borelli F AU - Morselli PG AU - Nouri N AU - Abdali H AU - Gianni AB AU - Russillo A AU - Docimo R AU - Martinelli M TI - Non-Syndromic Cleft Palate: Association Analysis on Three Gene Polymorphisms of the Folate Pathway in Asian and Italian Populations JO - International Journal of Immunopathology and Pharmacology VL - 33 IS - SP - EP - PY - 2019 ER -

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