Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients

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Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients Publisher Pubmed

Aghamohammadi A¹ ; Abolhassani H^{1, 2} ; Latif A¹ ; Tabassomi F¹ ; Shokuhfar T¹ ; Torabi Sagvand B¹ ; Shahinpour S¹ ; Mirminachi B¹ ; Parvaneh N¹ ; Movahedi M³ ; Gharagozlou M³ ; Sherkat R⁴ ; Amin R⁵ ; Aleyasin S⁵ Show All Authors

Aghamohammadi A¹
Abolhassani H^{1, 2}
Latif A¹
Tabassomi F¹
Shokuhfar T¹
Torabi Sagvand B¹
Shahinpour S¹
Mirminachi B¹
Parvaneh N¹
Movahedi M³
Gharagozlou M³
Sherkat R⁴
Amin R⁵
Aleyasin S⁵
Faridhosseini R⁶
Jabbariazad F⁷
Cheraghi T⁸
Eslamian MH^{1, 3}
Khalili A^{1, 3}
Kalantari N⁹
Shafiei A¹⁰
Dabbaghzade A^{1, 3}
Khayatzadeh A^{1, 3}
Ebrahimi M^{1, 3}
Razavinejad D¹
Bazregari S^{1, 3}
Ebrahimi M^{1, 3}
Ghaffari J¹¹
Bemanian MH¹²
Behniafard N^{1, 10}
Kashef S¹³
Mohammadzadeh I¹⁴
Hammarstrom L²
Rezaei N¹

Source: Expert Review of Clinical Immunology Published:2014

Abstract

Objectives: Common variable immune deficiency (CVID) is the most frequent form of symptomatic primary immunodeficiency disease, characterized by hypogammaglobulinemia, recurrent infections and increased predisposition to autoimmunity and malignancies. The aim of this study was to reconsider important points of previously performed studies on Iranian CVID patients diagnosed and followed from 1984 to 2013. Methods: Diagnosis was made using approved criteria including reductions of serum levels of immunoglobulins and exclusion of well-known single gene defects in individuals with an age >4 years and evidence of specific antibody deficiency. Results: Detailed information on demographic data, survival rates, clinical phenotypes, immunologic and genetic data and treatment of 173 patients are provided. The early onset presentation (74.5%) and rate of consanguineous marriage (61.2%) were considerably higher in our cohort. Our study revealed clinically related correlations regarding consanguinity, the population of naive CD4+T cells and switched-memory B cells, cytokine levels and special genetic factors (including HLA and AID genes). Conclusion: Despite current efforts, more comprehensive studies are needed, especially for classification and investigation of the genetic background and prognostic factors for patients with CVID in order to better managment and followup of patinets. © 2014 Informa UK, Ltd.

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Style	Citing Format
MLA	Aghamohammadi A, et al.. "Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients." Expert Review of Clinical Immunology, vol. 10, no. 10, 2014, pp. 1405-1417.
APA	Aghamohammadi A, Abolhassani H, Latif A, Tabassomi F, Shokuhfar T, Torabi Sagvand B, Shahinpour S, Mirminachi B, Parvaneh N, Movahedi M, Gharagozlou M, Sherkat R, Amin R, Aleyasin S, Faridhosseini R, Jabbariazad F, Cheraghi T, Eslamian MH, Khalili A, ... Rezaei N (2014). Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients. Expert Review of Clinical Immunology, 10(10), 1405-1417.
Chicago	Aghamohammadi A, Abolhassani H, Latif A, Tabassomi F, Shokuhfar T, Torabi Sagvand B, Shahinpour S, et al.. "Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients." Expert Review of Clinical Immunology 10, no. 10 (2014): 1405-1417.
Harvard	Aghamohammadi A et al. (2014) 'Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients', Expert Review of Clinical Immunology, 10(10), pp. 1405-1417.
Vancouver	Aghamohammadi A, Abolhassani H, Latif A, Tabassomi F, Shokuhfar T, Torabi Sagvand B, et al.. Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients. Expert Review of Clinical Immunology. 2014;10(10):1405-1417.
BibTex	@article{ author = {Aghamohammadi A and Abolhassani H and Latif A and Tabassomi F and Shokuhfar T and Torabi Sagvand B and Shahinpour S and Mirminachi B and Parvaneh N and Movahedi M and Gharagozlou M and Sherkat R and Amin R and Aleyasin S and Faridhosseini R and Jabbariazad F and Cheraghi T and Eslamian MH and Khalili A and Kalantari N and Shafiei A and Dabbaghzade A and Khayatzadeh A and Ebrahimi M and Razavinejad D and Bazregari S and Ebrahimi M and Ghaffari J and Bemanian MH and Behniafard N and Kashef S and Mohammadzadeh I and Hammarstrom L and Rezaei N}, title = {Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients}, journal = {Expert Review of Clinical Immunology}, volume = {10}, number = {10}, pages = {1405-1417}, year = {2014} }
RIS	TY - JOUR AU - Aghamohammadi A AU - Abolhassani H AU - Latif A AU - Tabassomi F AU - Shokuhfar T AU - Torabi Sagvand B AU - Shahinpour S AU - Mirminachi B AU - Parvaneh N AU - Movahedi M AU - Gharagozlou M AU - Sherkat R AU - Amin R AU - Aleyasin S AU - Faridhosseini R AU - Jabbariazad F AU - Cheraghi T AU - Eslamian MH AU - Khalili A AU - Kalantari N AU - Shafiei A AU - Dabbaghzade A AU - Khayatzadeh A AU - Ebrahimi M AU - Razavinejad D AU - Bazregari S AU - Ebrahimi M AU - Ghaffari J AU - Bemanian MH AU - Behniafard N AU - Kashef S AU - Mohammadzadeh I AU - Hammarstrom L AU - Rezaei N TI - Long-Term Evaluation of a Historical Cohort of Iranian Common Variable Immunodeficiency Patients JO - Expert Review of Clinical Immunology VL - 10 IS - 10 SP - 1405 EP - 1417 PY - 2014 ER -