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Formulation of Electrospun Mg-Fa/Poly (Ε-Caprolactone) Nanocomposite to Adjust Bioactivity, Biodegradability, and Cellular Interactions Publisher



Fereshteh Z1, 2, 3 ; Fathi M3, 4 ; Kargozar S5 ; Samadikuchaksaraei A6, 7, 8
Authors
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Authors Affiliations
  1. 1. Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY, United States
  2. 2. Department of Biomedical Engineering, University of Delaware, Newark, DE, United States
  3. 3. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
  4. 4. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Polymers for Advanced Technologies Published:2021


Abstract

Adjusting the biological properties of scaffolds is one of the most challenging issues in tissue engineering. Here, we focus on formulating a nanocomposite with tunability for bioactivity, biodegradability, and cellular interactions by using different nanoparticles composition and concentration. Here, after optimizing Mg+2 ions concentration in fluorapatite nanoparticles (Mg-FA NPs), we probed the influence of Mg-FA NPs on the biological properties of the electrospun Mg-FA/poly (ε-caprolactone). Increasing Mg-FA nanoparticles up to 15 wt% in the composite could enhance the bioactivity from 0.02 wt% in the pure PCL scaffold up to 3 wt% (150 times more) by gaining weight after 28-day incubation in simulated body fluid (SBF) at 37°C. In the same order, the biodegradation of scaffolds accelerated from 3.1 wt% to 34.6 wt% (11 times more). The cell attachment assays, using MG-63, showed that the presence of Mg-FA NPs plays a crucial role to attach cells on the surface by improving wettability as well as biocompatibility. Also, the Mg-FA NPs encouraged MG-63 cells to proliferate on/inside the scaffolds and generate 3D cell networks. © 2021 John Wiley & Sons Ltd.
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