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Synthesis and Characterization of Core-Shell Fe 3O 4-Gold-Chitosan Nanostructure Publisher Pubmed



Salehizadeh H1, 2 ; Hekmatian E3 ; Sadeghi M2 ; Kennedy K1
Authors

Source: Journal of Nanobiotechnology Published:2012


Abstract

Background: Fe 3O 4-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment.Results: Magnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe 3O 4 monotonous core-shell nanostructure was produced with an average size of 15 nm in diameter by glucose reduction of Au 3+ which is then stabilized with a chitosan cross linked by formaldehyde. The results of analyses with X-ray diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution.Conclusions: A rapid, mild method for synthesizing Fe 3O 4-gold nanoparticles using chitosan was investigated. A magnetic core-shell-chitosan nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized. © 2012 Salehizadeh et al; licensee BioMed Central Ltd.
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