Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions

Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions Publisher Pubmed

Kefayat A^{1, 2} ; Ghahremani F³ ; Motaghi H⁴ ; Rostami S⁵ ; Mehrgardi MA⁴

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1. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Oncology, Seyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3. Department of Medical Physics & Radiotherapy, School of Medicine, Arak University of Medical Sciences, Arak, Iran
4. Department of Chemistry, University of Isfahan, Isfahan, Iran
5. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Drug Targeting Published:2019

Abstract

In the present study, alive attenuated Salmonella typhi Ty21a was introduced as a vehicle for smart delivery of gold nanoparticles to the tumours’ hypoxic regions. At the first step, the uptakes of gold nanoparticles with seven different decorations by S. typhi Ty21a was investigated using flow cytometry and inductively coupled plasma optical emission spectroscopy. The analyses demonstrated that folic acid functionalised gold nanoparticles (FA-GNPs) are the best candidates for producing the Golden Bacteria (GB). Subsequently, the GB and FA-GNPs efficacies for tumour targeting were investigated after intravenous injection to CT-26 tumour-bearing mice. The GB exhibited more GNPs delivery to the tumour in comparison with FA-GNPs. Moreover, GB injection causes more delivery of GNPs to the tumours’ central regions in comparison with tumours’ periphery. This trend is completely in reverse for FA-GNPs injected group. The ratios of peripheral to central regions’ gold concentration of the tumours were 1.95 ± 0.13 and 0.61 ± 0.10 for FA-GNPs and GB groups, respectively. This observation demonstrates higher accumulation of gold nanoparticles in the centre of the tumour due to their active delivery by the S. typhi Ty21a to the deeps of tumours. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Kefayat A, et al.. "Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions." Journal of Drug Targeting, vol. 27, no. 3, 2019, pp. 315-324.
APA	Kefayat A, Ghahremani F, Motaghi H, Rostami S, Mehrgardi MA (2019). Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions. Journal of Drug Targeting, 27(3), 315-324.
Chicago	Kefayat A, Ghahremani F, Motaghi H, Rostami S, Mehrgardi MA. "Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions." Journal of Drug Targeting 27, no. 3 (2019): 315-324.
Harvard	Kefayat A et al. (2019) 'Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions', Journal of Drug Targeting, 27(3), pp. 315-324.
Vancouver	Kefayat A, Ghahremani F, Motaghi H, Rostami S, Mehrgardi MA. Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions. Journal of Drug Targeting. 2019;27(3):315-324.
BibTex	@article{ author = {Kefayat A and Ghahremani F and Motaghi H and Rostami S and Mehrgardi MA}, title = {Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions}, journal = {Journal of Drug Targeting}, volume = {27}, number = {3}, pages = {315-324}, year = {2019} }
RIS	TY - JOUR AU - Kefayat A AU - Ghahremani F AU - Motaghi H AU - Rostami S AU - Mehrgardi MA TI - Alive Attenuated Salmonella As a Cargo Shuttle for Smart Carrying of Gold Nanoparticles to Tumour Hypoxic Regions JO - Journal of Drug Targeting VL - 27 IS - 3 SP - 315 EP - 324 PY - 2019 ER -

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