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Association of Interleukin-10 -1082G > a Polymorphism With Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Based on 21 Studies Publisher Pubmed



Veisian M1 ; Tabatabaei RS2 ; Javaheri A2 ; Abbasi H3 ; Salimi E3 ; Hadadan A3 ; Zanbagh L2 ; Dastgheib SA4 ; Neamatzadeh H5, 6
Authors
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Authors Affiliations
  1. 1. Department of Gynecology and Obstetrics, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Fetal and Pediatric Pathology Published:2020


Abstract

Background: Previous studies have reported the association between IL-10 -1082 G > A polymorphism and preeclampsia risk, but the results remained controversial. Therefore, this meta-analysis was performed to evaluate the association of IL-10 -1082 G > A polymorphism with preeclampsia risk. Methods: We searched PubMed, ISI Web of Knowledge and CNKI databases to identify eligible studies up to September 05, 2019. Results: A total of 21 case-control studies with 3,510 cases and 5,874 controls were selected. The results revealed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia under the recessive model (AA vs. AG + GG: OR = 1.191, 95% CI = 1.018–1.394, P = 0.029). Stratified analyses by ethnicity revealed a significantly increased risk of preeclampsia in Asian and mixed populations, but not in Caucasians. Moreover, there was a significant association among Chinese and Brazilian. Conclusions: Our results showed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia. © 2019 Taylor & Francis Group, LLC.
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