Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Systems Biology Unravels the Relationship of Lncrna Oip5-As1 With Cd25 Publisher



Dehbashi M1 ; Hojati Z1 ; Motovalibashi M1 ; Cho WC2 ; Shimosaka A3 ; Ganjalikhanihakemi M4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  2. 2. Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
  3. 3. Institute of Hematology, Peking Union Medical College, Beijing, China
  4. 4. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Gene Reports Published:2021


Abstract

The regulatory T cells function in the immune homeostasis, these cells express high level of CD25. It is known that CD25 expression levels are various among different cancers. Thus, we intended to dissect systems biology of a lncRNA pertained to CD25 and CD25 protein interactors-targeting miRNAs. Using RNA-seq data, co-expression analyses of the lncRNA pertained to some cancers were performed. Our analysis was done for protein interactors of CD25 by STRING 11.0, ShinyGO v0.60 and KEGG web servers were used for enrichment and network analysis of CD25. TargetScan 7.2, miRTargetLink Human and mirDIP were applied for determining the CD25 and CD25 interactors-targeting miRNAs. To find the lncRNA-miRNA and lncRNA-protein interactions, starBase v3.0, LncBase Predicted v.2 and SFPEL-LPI were utilized, respectively. Also, using Co-LncRNA, the co-expressed lncRNA analysis and the relative signaling pathways in some cancers including bladder, breast, head and neck, kidney, liver, lung, prostate and thyroid cancers using RNA-seq data were achieved. OIP5-AS1 was shown to have the interaction with CD25 and CD25 protein interactors-targeting miRNAs. In addition, the co-expression of OIP5-AS1 in cancers and their signaling pathways was identified. In conclusion, OIP5-AS1 can effect on CD25 expression in all relative signaling pathways of these cancers. © 2021 Elsevier Inc.
Related Docs
View other Related Docs
1. Computational Study for Suppression of Cd25/Il-2 Interaction, Biological Chemistry (2021)
2. Construction of a Cell Cycle-Specific Lncrna-Mirna-Mrna Network Reveals Novel Key Lncrnas in Colorectal Cancer, Biomarkers (2024)
3. New Long Noncoding Rna Biomarkers and Cerna Networks on Mir‑616‑3P in Colorectal Cancer: Bioinformatics‑Based Study, Journal of Research in Medical Sciences (2024)
4. Integral Membrane Protein Expression of Human Cd25 on the Cell Surface of Hek293 Cell Line: The Available Cellular Model of Cd25 Positive to Facilitate in Vitro Developing Assays, Biomolecular Concepts (2019)
5. Comprehensive Competitive Endogenous Rna Network Analysis Reveals Ezh2-Related Axes and Prognostic Biomarkers in Hepatocellular Carcinoma, Iranian Journal of Basic Medical Sciences (2022)
6. Identification of Syt10 As a Potential Prognostic Biomarker in Esophageal Cancer by Comprehensive Analysis of a Mrna-Pseudogene/Lncrna-Mirna Cerna Network, Human Gene (2023)
7. The Prominent Role of Mir-942 in Carcinogenesis of Tumors, Advanced Biomedical Research (2022)
8. Exploring Conserved Mrna-Mirna Interactions in Colon and Lung Cancers, Gastroenterology and Hepatology from Bed to Bench (2017)
Experts (# of related papers)
View all Related Experts
Parvaneh Nikpour (3)
Mazdak Ganjalikhani Hakemi (3)
Other Related Docs
9. An Integrated Bioinformatics Analysis of the Potential Regulatory Effects of Mir-21 on T-Cell Related Target Genes in Multiple Sclerosis, Avicenna Journal of Medical Biotechnology (2021)
10. Mir-196: Emerging of a New Potential Therapeutic Target and Biomarker in Colorectal Cancer, Molecular Biology Reports (2020)
11. An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers, Pathology Research and Practice (2023)
12. Multiple Function of Lncrna Malat1 in Cancer Occurrence and Progression, Chemical Biology and Drug Design (2023)
13. Lncrna–Mirna–Mrna Networks of Gastrointestinal Cancers Representing Common and Specific Lncrnas and Mrnas, Frontiers in Genetics (2022)
14. Targetome Analysis Revealed Involvement of Mir-126 in Neurotrophin Signaling Pathway: A Possible Role in Prevention of Glioma Development, Cell Journal (2018)
15. Dysregulated of the Fam138e and Clrn1-As1 Lncrnas Could Be Diagnosis Biomarkers in Colorectal Cancer, Human Gene (2024)
16. Long Non-Coding Rnas As Potential Biomarkers or Therapeutic Targets in Gastric Cancer, Gastroenterology and Hepatology from Bed to Bench (2023)
17. Lncrna Flvcr1-As1 Sponges Mir-381-3P and Promotes Wnt Signaling Pathway Resulting in Colorectal Cancer Progression, Egyptian Journal of Medical Human Genetics (2025)
18. Therapeutic Inhibition of Microrna-21 (Mir-21) Using Locked-Nucleic Acid (Lna)-Anti-Mir and Its Effects on the Biological Behaviors of Melanoma Cancer Cells in Preclinical Studies, Cancer Cell International (2020)
19. Mir-574, Mir-499, Mir-125B, Mir-106A, and Mir-9 Potentially Target Tgfbr-1 and Tgfbr-2 Genes Involving in Inflammatory Response Pathway: Potential Novel Biomarkers for Chronic Lymphocytic Leukemia, Pathology Research and Practice (2022)
20. In Silico Identification and in Vitro Evaluation of Mrps30-Dt Lncrna and Mrps30 Gene Expression in Breast Cancer, Cancer Reports (2024)
21. A Novel Car Expressing Nk Cell Targeting Cd25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers, Frontiers in Oncology (2021)
22. Analysis of a Four-Component Competing Endogenous Rna Network Reveals Potential Biomarkers in Gastric Cancer: An Integrated Systems Biology and Experimental Investigation, Advanced Biomedical Research (2023)
23. A Review on Expression and Regulatory Mechanisms of Mir-337-3P in Cancer, Journal of Biomolecular Structure and Dynamics (2024)
24. Lna Inhibitor in Microrna Mir-23B As a Potential Anti-Proliferative Option in Human Hepatocellular Carcinoma, Journal of Gastrointestinal Cancer (2020)
25. Modulation of Long Non-Coding Rnas by Resveratrol As a Potential Therapeutic Approach in Cancer: A Comprehensive Review, Pathology Research and Practice (2023)
26. A Pan-Cancer Analysis Indicates Long Noncoding Rna Hand2-As1 As a Potential Prognostic, Immunomodulatory and Therapeutic Biomarker in Various Cancers Including Colorectal Adenocarcinoma, Cancer Cell International (2023)
27. Identification of Significant Genes and Pathways Associated With Tenascin-C in Cancer Progression by Bioinformatics Analysis, Advanced Biomedical Research (2022)
28. Microrna-196A As a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma, Cancer Investigation (2017)
29. Deregulation of Mir-1245B-5P and Mir-92A-3P and Their Potential Target Gene, Gata3, in Epithelial–Mesenchymal Transition Pathway in Breast Cancer, Cancer Reports (2024)
30. In-Silico Identification of Therapeutic Targets in Pancreatic Ductal Adenocarcinoma Using Wgcna and Trader, Scientific Reports (2024)
31. Mir-1236: Key Controller of Tumor Development and Progression: Focus on the Biological Functions and Molecular Mechanisms, Pathology Research and Practice (2023)
32. A Computational Framework to Infer Prostate Cancer-Associated Long Noncoding Rnas and Analyses for Identifying a Competing Endogenous Rna Network, Genetic Testing and Molecular Biomarkers (2021)