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Microrna-196A As a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma Publisher Pubmed



Fendereski M1 ; Zia MF2 ; Shafiee M3 ; Safari F1 ; Saneie MH4 ; Tavassoli M1
Authors
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Department of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Isfahan University of Medical Sciences, Gorgan, Iran
  3. 3. Department of Medical Genetics, School of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Cancer Investigation Published:2017


Abstract

We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p =.002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC. In addition, molecular pathway enrichment analysis of microRNA (miR)-196a determined focal adhesion, spliceosome and p53 signaling pathways as the most relevant pathways with miR-196a targetome. © 2017 Taylor & Francis Group, LLC.
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