Paper Details

Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Faculty Members have conducted research related to the Metformin Therapy Attenuates Pro-Inflammatory Microglia by Inhibiting Nf-Κb in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis

Parichehr Pasbakhsh

Parichehr Pasbakhsh

Professor of Anatomical Sciences

Department Anatomy

School of Medicine

Tehran University of Medical Sciences

Related Documents

1. Metformin Therapy Attenuates Pro-Inflammatory Microglia by Inhibiting Nf-Κb in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis, Neurotoxicity Research (2021)

2. Microglia Polarization by Methylprednizolone Acetate Accelerates Cuprizone Induced Demyelination, Journal of Molecular Histology (2018)

3. Microglia/Macrophage Polarization Regulates Spontaneous Remyelination in Intermittent Cuprizone Model of Demyelination, Biochemistry and Biophysics Reports (2024)

4. Effect of the Csf1r Inhibitor Plx3397 on Remyelination of Corpus Callosum in a Cuprizone-Induced Demyelination Mouse Model, Journal of Cellular Biochemistry (2019)

5. Progesterone Therapy Induces an M1 to M2 Switch in Microglia Phenotype and Suppresses Nlrp3 Inflammasome in a Cuprizone-Induced Demyelination Mouse Model, International Immunopharmacology (2017)

6. Oligoprotective Effect of Metformin Through the Ampk-Dependent on Restoration of Mitochondrial Hemostasis in the Cuprizone-Induced Multiple Sclerosis Model, Journal of Molecular Histology (2019)

7. Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction, Cellular and Molecular Neurobiology (2021)

8. Intranasal Delivery of Sdf-1Α-Preconditioned Bone Marrow Mesenchymal Cells Improves Remyelination in the Cuprizone-Induced Mouse Model of Multiple Sclerosis, Cell Biology International (2020)

9. Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination, Neurotoxicity Research (2022)

10. Astrocyte Ablation Induced by La-Aminoadipate (L-Aaa) Potentiates Remyelination in a Cuprizone Demyelinating Mouse Model, Metabolic Brain Disease (2019)

11. The Effect of Microglial Ablation and Mesenchymal Stem Cell Transplantation on a Cuprizone-Induced Demyelination Model, Journal of Cellular Physiology (2021)

All Documents

1. Retraction Note To: Preconditioning With Melatonin Improves Therapeutic Outcomes of Bone Marrow-Derived Mesenchymal Stem Cells in Targeting Liver Fibrosis Induced by Ccl4 (Cell and Tissue Research, (2017), 369, 2, (303-312), 10.1007/S00441-017-2604-1), Cell and Tissue Research (2025)

2. Valproic Acid Preconditioning of Bone Marrow Mesenchymal Stem Cells Promotes Remyelination of the Corpus Callosum in a Cuprizone-Induced Demyelination Model, Biomedicine and Pharmacotherapy (2025)

3. Benefits of Bone Marrow Mesenchymal Stem Cells Compared to Their Conditioned Medium in Valproic Acid-Induced Autism in Rats, Molecular Biology Reports (2024)

4. Correction To: Calorie Restriction Promotes Remyelination in a Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis (Metabolic Brain Disease, (2020), 35, 7, (1211-1224), 10.1007/S11011-020-00597-0), Metabolic Brain Disease (2024)

5. Microglia/Macrophage Polarization Regulates Spontaneous Remyelination in Intermittent Cuprizone Model of Demyelination, Biochemistry and Biophysics Reports (2024)

6. Correction To: Astrocyte Ablation Induced by La-Aminoadipate (L-Aaa) Potentiates Remyelination in a Cuprizone Demyelinating Mouse Model (Metabolic Brain Disease, (2019), 34, 2, (593-603), 10.1007/S11011-019-0385-9), Metabolic Brain Disease (2023)

7. Correction To: Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone‑Induced Demyelination Mouse Model (Molecular Neurobiology, (2022), 59, 12, (7278-7292), 10.1007/S12035-022-03036-6), Molecular Neurobiology (2023)

8. Effects of Calorie Restriction on Multiple Sclerosis: A Review of the Preclinical and Clinical Studies, Neurochemical Research (2023)

9. Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone-Induced Demyelination Mouse Model, Molecular Neurobiology (2022)

10. Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination, Neurotoxicity Research (2022)

11. 17Β-Estradiol Reduces Demyelination in Cuprizone-Fed Mice by Promoting M2 Microglia Polarity and Regulating Nlrp3 Inflammasome, Neuroscience (2021)

12. Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction, Cellular and Molecular Neurobiology (2021)

13. Metformin Therapy Attenuates Pro-Inflammatory Microglia by Inhibiting Nf-Κb in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis, Neurotoxicity Research (2021)

14. Protective Features of Calorie Restriction on Cuprizone-Induced Demyelination Via Modulating Microglial Phenotype, Journal of Chemical Neuroanatomy (2021)

15. The Effect of Microglial Ablation and Mesenchymal Stem Cell Transplantation on a Cuprizone-Induced Demyelination Model, Journal of Cellular Physiology (2021)

16. Calorie Restriction Promotes Remyelination in a Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis, Metabolic Brain Disease (2020)

17. Effects of Exogenous Melatonin on Mam Induced Lung Injury and Lung Development in Mice Offspring, Tanaffos (2020)

18. Intranasal Delivery of Sdf-1Α-Preconditioned Bone Marrow Mesenchymal Cells Improves Remyelination in the Cuprizone-Induced Mouse Model of Multiple Sclerosis, Cell Biology International (2020)

19. The Effect of Melatonin on Mitochondrial Function and Autophagy in in Vitro Matured Oocytes of Aged Mice, Cell Journal (2020)

20. The Role of Thyroid Diseases and Their Medications in Cardiovascular Disorders: A Review of the Literature, Current Cardiology Reviews (2020)

21. Astrocyte Ablation Induced by La-Aminoadipate (L-Aaa) Potentiates Remyelination in a Cuprizone Demyelinating Mouse Model, Metabolic Brain Disease (2019)

22. Effect of the Csf1r Inhibitor Plx3397 on Remyelination of Corpus Callosum in a Cuprizone-Induced Demyelination Mouse Model, Journal of Cellular Biochemistry (2019)

23. Melatonin Preconditioning of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Their Engraftment and Improves Renal Regeneration in a Rat Model of Chronic Kidney Disease, Journal of Molecular Histology (2019)

24. Oligoprotective Effect of Metformin Through the Ampk-Dependent on Restoration of Mitochondrial Hemostasis in the Cuprizone-Induced Multiple Sclerosis Model, Journal of Molecular Histology (2019)

25. Preconditioning With Sdf-1 Improves Therapeutic Outcomes of Bone Marrow-Derived Mesenchymal Stromal Cells in a Mouse Model of Stz-Induced Diabetes, Avicenna Journal of Medical Biotechnology (2019)

26. Embryonic Intraventricular Transplantation of Neural Stem Cells Augments Inflammation-Induced Prenatal Brain Injury, Journal of Chemical Neuroanatomy (2018)

27. Melatonin Pretreated Blastocysts Along With Calcitonin Administration Improved Implantation by Upregulation of Heparin Binding-Epidermal Growth Factor Expression in Murine Endometrium, Cell Journal (2018)

28. Microglia Polarization by Methylprednizolone Acetate Accelerates Cuprizone Induced Demyelination, Journal of Molecular Histology (2018)

29. Resveratrol Pretreatment Enhanced Homing of Sdf-1Α-Preconditioned Bone Marrow-Derived Mesenchymal Stem Cells in a Rat Model of Liver Cirrhosis, Journal of Cellular Biochemistry (2018)

30. Therapeutic Effect of Perinatal Exogenous Melatonin on Behavioral and Histopathological Changes and Antioxidative Enzymes in Neonate Mouse Model of Cortical Malformation, International Journal of Developmental Neuroscience (2018)

31. A Case Based-Shared Teaching Approach in Undergraduate Medical Curriculum: A Way for Integration in Basic and Clinical Sciences, Acta Medica Iranica (2017)

32. Melatonin Upregulates Erbb1 and Erbb4, Two Primary Implantation Receptors, in Pre-Implantation Mouse Embryos, Iranian Journal of Basic Medical Sciences (2017)

33. Preconditioning With Melatonin Improves Therapeutic Outcomes of Bone Marrow-Derived Mesenchymal Stem Cells in Targeting Liver Fibrosis Induced by Ccl4, Cell and Tissue Research (2017)

34. Progesterone Therapy Induces an M1 to M2 Switch in Microglia Phenotype and Suppresses Nlrp3 Inflammasome in a Cuprizone-Induced Demyelination Mouse Model, International Immunopharmacology (2017)

35. Protective Effects of Erythropoietin Against Cuprizone-Induced Oxidative Stress and Demyelination in the Mouse Corpus Callosum, Iranian Journal of Basic Medical Sciences (2017)

36. Role of Stromal Derived Factor-1A (Sdf-1A) for Spermatogenesis of Busulfan-Injured Rats, Reproductive Toxicology (2017)

37. Effect of Human Recombinant Granulocyte Colony-Stimulating Factor on Rat Busulfan-Induced Testis Injury, Journal of Molecular Histology (2016)

38. In Vitro Differentiation of Insulin Secreting Cells From Mouse Bone Marrow Derived Stage-Specific Embryonic Antigen 1 Positive Stem Cells, Cell Journal (2016)

39. Melatonin Pretreatment Enhances the Homing of Bone Marrow-Derived Mesenchymal Stem Cells Following Transplantation in a Rat Model of Liver Fibrosis, Iranian Biomedical Journal (2016)

40. Regulatory Effect of Triiodothyronine on Brain Myelination and Astrogliosis After Cuprizone-Induced Demyelination in Mice, Metabolic Brain Disease (2016)

41. Therapeutic Value of Melatonin Post-Treatment on Ccl4-Induced Fibrotic Rat Liver, Canadian Journal of Physiology and Pharmacology (2016)

42. Do Pilea Microphylla Improve Sperm Dna Fragmentation and Sperm Parameters in Varicocelized Rats?, Acta medica Iranica (2015)

43. Do Pilea Microphylla Improve Sperm Dna Fragmentation and Sperm Parameters in Varicocelized Rats?, Acta Medica Iranica (2015)

44. Intravenous Transplantation of Very Small Embryonic Like Stem Cells in Treatment of Diabetes Mellitus, Avicenna Journal of Medical Biotechnology (2015)

45. Progesterone Enhanced Remyelination in the Mouse Corpus Callosum After Cuprizone Induced Demyelination, Iranian Journal of Medical Sciences (2015)

46. Retinoic Acid As the Stimulating Factor for Differentiation of Wharton’S Jelly– Mesenchymal Stem Cells Into Hepatocyte-Like Cells, Avicenna Journal of Medical Biotechnology (2015)

47. Trimetazidine Prevents Oxidative Changes Induced in a Rat Model of Sporadic Type of Alzheimer΄S Disease, Acta Medica Iranica (2015)