Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Lysine Ε-Aminolysis and Incorporation of Sulfhydryl Groups Into Human Brain Tau 4R/1N and 306Vqivyk311 Enhances the Formation of Beta Structures and Toxicity
Azadeh Ebrahim-Habibi

Professor of Biochemistry

Biosensor Research Center

Endocrinology and Metabolism Research Institute

Tehran University of Medical Sciences

All Documents
1. Dead-End Protein Expression, Function, and Mutation in Cancer: A Systematic Review, Molecular Biology Reports (2025)
2. Comprehensive Investigation of Insulin-Induced Amyloidosis Lesions in Patients With Diabetes at Clinical and Histological Levels: A Systematic Review, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2024)
3. Decoding the Structure–Function Relationship of the Muramidase Domain in E. Coli O157.H7 Bacteriophage Endolysin: A Potential Building Block for Chimeric Enzybiotics, Protein Journal (2024)
4. Effect of Thioflavin-T on Adipokine Hormones and Fatty Liver in Obese Male Nmri Mice Fed a High-Fat Diet, Physiology and Pharmacology (Iran) (2024)
5. Emergence of Sweet Ligand-Protein Complexes From Seemingly Non-Sweet Conformations, Journal of Molecular Liquids (2024)
6. Phenylalanine As an Effective Stabilizer and Aggregation Inhibitor of Bacillus Amyloliquefaciens Alpha-Amylase, AMB Express (2024)
7. Structural Insights Into the Pathogenicity of Point Mutations in Human Acyl-Coa Dehydrogenase Homotetramers, Journal of Biological Physics (2024)
8. Chemical Modification of the Amino Groups of Human Insulin: Investigating Structural Properties and Amorphous Aggregation of Acetylated Species, Protein Journal (2023)
9. Correction To: Drug Repurposing Using Computational Methods to Identify Therapeutic Options for Covid-19 (Journal of Diabetes & Metabolic Disorders, (2020), 19, 2, (691-699), 10.1007/S40200-020-00546-9), Journal of Diabetes and Metabolic Disorders (2023)
10. Effect of Silibinin and Trans-Chalcone in an Alzheimer’S Disease-Like Model Generated by Insulin Amyloids, Brazilian Journal of Medical and Biological Research (2023)
11. Pegylated Pamam Dendrimers As Eptifibatide Nanocarriers: An Atomistic View From Molecular Dynamics Simulations, Chemical Engineering Science (2023)
12. Unfolding of an Alpha-Helical Peptide Exposed to High Temperature: Suggesting a Critical Residue in the Process, Structural Chemistry (2023)
13. A Study on Alpha-Terpineol in Alzheimer’S Disease With the Use of Rodent in Vivo Model, Restraint Stress Effect and in Vitro Amyloid Beta Fibrils, Brazilian Journal of Pharmaceutical Sciences (2022)
14. Local Insulin-Derived Amyloidosis Model Confronted With Silymarin: Histological Insights and Gene Expression of Mmp, Tnf-Α, and Il-6, International Journal of Molecular Sciences (2022)
15. Phenylalanine and Indole Effects on the Pathogenicity of Human Lysozyme Amorphous Aggregates, Enzyme and Microbial Technology (2022)
16. Structural Modeling of Human Akap3 Protein and in Silico Analysis of Single Nucleotide Polymorphisms Associated With Sperm Motility, Scientific Reports (2022)
17. 5-[Aryloxypyridyl (Or Nitrophenyl)]-4H-1,2,4-Triazoles As Novel Flexible Benzodiazepine Analogues: Synthesis, Receptor Binding Affinity and Lipophilicity-Dependent Anti-Seizure Onset of Action, Bioorganic Chemistry (2021)
18. Hydro Alcoholic Green Tea Extract Effect on High Fat Diet Treated Nmri Mice and 3T3l1 Cells, Journal of Diabetes and Metabolic Disorders (2021)
19. Modeling and Simulation in Medical Sciences: An Overview of Specific Applications Based on Research Experience in Emri (Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences), Journal of Diabetes and Metabolic Disorders (2021)
20. Pamam and Polyester Dendrimers As Favipiravir Nanocarriers: A Comparative Study Using Dft Method, Journal of Nanoparticle Research (2021)
21. Structure-Sweetness Relationship of Sweet Proteins: A Systematic Review on “Sweet Protein” Studies As a Sub-Group of “Sweetener” Investigations, Moscow University Biological Sciences Bulletin (2021)
22. The Therapeutic Effects of Berberine Plus Sitagliptin in a Rat Model of Fatty Liver Disease, Iranian Journal of Basic Medical Sciences (2021)
23. Betanin Effect on Ppar-Α and Srebp-1C Expression in Nmri Mice Model of Steatohepatitis With Fibrosis, Physiology International (2020)
24. Characterization of Arginine Preventive Effect on Heat-Induced Aggregation of Insulin, International Journal of Biological Macromolecules (2020)
25. Cymene Consumption and Physical Activity Effect in Alzheimer’S Disease Model: An in Vivo and in Vitro Study, Journal of Diabetes and Metabolic Disorders (2020)
26. Drug Repurposing Using Computational Methods to Identify Therapeutic Options for Covid-19, Journal of Diabetes and Metabolic Disorders (2020)
27. Engineering an Anti-Granulocyte Colony Stimulating Factor Receptor Nanobody for Improved Affinity, Life Sciences (2020)
28. Engineering an Anti-Granulocyte Colony Stimulating Factor Receptor Nanobody for Improved Affinity, Life Sciences (2020)
29. Glycyrrhizin Improves Fatty Liver Symptoms, Increases Adiponectin and Reduces Ucp2 Expression in Wistar Rats, Proceedings of the National Academy of Sciences India Section B - Biological Sciences (2020)
30. Investigating the Role of Endogenous Opioid System in Chloroquine-Induced Phospholipidosis in Rat Liver by Morphological, Biochemical and Molecular Modelling Studies, Clinical and Experimental Pharmacology and Physiology (2020)
31. Investigation of Host-Guest Interactions Between Polyester Dendrimers and Ibuprofen Using Density Functional Theory (Dft), Computational and Theoretical Chemistry (2020)
32. A Simple Method for Inducing Nonalcoholic Steatohepatitis With Fibrosis, Animal Models and Experimental Medicine (2019)
33. A Systematic Review on Popularity, Application and Characteristics of Protein Secondary Structure Prediction Tools, Current Drug Discovery Technologies (2019)
34. Amino Acids As Additives Against Amorphous Aggregation: In Vitro and in Silico Study on Human Lysozyme, Applied Biochemistry and Biotechnology (2019)
35. Aurones As New Porcine Pancreatic Α-Amylase Inhibitors, Letters in Drug Design and Discovery (2019)
36. Effects of Eugenol on Alzheimer’S Disease-Like Manifestations in Insulin- and Aβ-Induced Rat Models, Neurophysiology (2019)
37. Influence of Dendrimer Surface Chemistry and Ph on the Binding and Release Pattern of Chalcone Studied by Molecular Dynamics Simulations, Journal of Molecular Recognition (2019)
38. Inhibition of Amyloid Fibrillation of Apo-Carbonic Anhydrase by Flavonoid Compounds, Journal of Biosciences (2019)
39. Introducing a New Model of Sweet Taste Receptor, a Class C G-Protein Coupled Receptor (C Gpcr), Cell Biochemistry and Biophysics (2019)
40. Monocyclic Phenolic Compounds Stabilize Human Insulin and Suppress Its Amorphous Aggregation: In Vitro and in Vivo Study, Biochemical and Biophysical Research Communications (2019)
41. Presence of Carbohydrate Binding Modules in Extracellular Region of Class C G-Protein Coupled Receptors (C Gpcr): An in Silico Investigation on Sweet Taste Receptor, Journal of Biosciences (2019)
42. Virtual Screening of Henna Compounds Library for Discovery of New Leads Against Human Thymidine Phosphorylase, an Overexpressed Factor of Hand-Foot Syndrome, Letters in Drug Design and Discovery (2019)
43. Acetylation of Lysine Residues in Apomyoglobin: Structural Changes, Amyloid Fibrillation, and Role of Surface Charge, International Journal of Biological Macromolecules (2018)
44. Astaxanthin Effectiveness in Preventing Multiple Sclerosis in Animal Model, Bratislava Medical Journal (2018)
45. Citral Effect in Male Nmri Mice Nonalcoholic Steatosis Model: Assessing Biochemical and Histological Parameters and Pparα Gene Expression, Brazilian Journal of Pharmaceutical Sciences (2018)
46. Effects of Thymol on Amyloid-Β-Induced Impairments in Hippocampal Synaptic Plasticity in Rats Fed a High-Fat Diet, Brain Research Bulletin (2018)
47. The Effects of Betanin of Beetroot in Polycystic Ovary Syndrome Induced Rat, Journal of Medicinal Plants (2018)
48. Atomistic Computer Simulations on Multi-Loaded Pamam Dendrimers: A Comparison of Amine- and Hydroxyl-Terminated Dendrimers, Journal of Computer-Aided Molecular Design (2017)
49. Characterization of Surface Binding Sites in Glycoside Hydrolases: A Computational Study, Journal of Molecular Recognition (2017)
50. Complexation of Nicotinic Acid With First Generation Poly(Amidoamine) Dendrimers: A Microscopic View From Density Functional Theory, Chemical Physics Letters (2017)
51. Effect of Organic Solvents on Porcine Pancreatic Lipase Thermal Aggregation, Protein and Peptide Letters (2017)
52. Human Serum Albumin Structure in Presence of Different Concentrations of Cortisol and Glucose: An in Vitro Modeling Under Normal and Hyperglycemic Conditions, Iranian Red Crescent Medical Journal (2017)
53. Indole-Based Derivatives Effect on Rats With Polycystic Ovary Syndrome, Journal of Pharmaceutical Investigation (2017)
54. Investigation of Thymol Effect on Learning and Memory Impairment Induced by Intrahippocampal Injection of Amyloid Beta Peptide in High Fat Diet- Fed Rats, Metabolic Brain Disease (2017)
55. Liver Alpha-Amylase Gene Expression As an Early Obesity Biomarker, Pharmacological Reports (2017)
56. Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity, Archives Italiennes de Biologie (2017)
57. Structure and Function of Anhydride-Modified Forms of Human Insulin: In Silico, in Vitro and in Vivo Studies, European Journal of Pharmaceutical Sciences (2017)
58. Therapeutic Protein Deimmunization by T-Cell Epitope Removal: Antigen-Specific Immune Responses in Vitro and in Vivo, APMIS (2017)
59. Turmeric Effect on Subcutaneous Insulin-Induced Amyloid Mass: An in Vivo Study, Drug and Chemical Toxicology (2017)
60. Acarbose and the Thermal Aggregation of Bacillus Amyloliquefaciens Alpha-Amylase (Baa): Protective Effect of an Inhibitor, Journal of Chemical Technology and Biotechnology (2016)
61. Amyloid-Like Aggregates Formation by Bovine Apo-Carbonic Anhydrase in Various Alcohols: A Comparative Study, International Journal of Biological Macromolecules (2016)
62. Benzothiazole Thioflavin T Improves Obesity-Related Symptoms in Mice, Periodicum Biologorum (2016)
63. Bis(Indolyl)Phenylmethane Derivatives Are Effective Small Molecules for Inhibition of Amyloid Fibril Formation by Hen Lysozyme, European Journal of Medicinal Chemistry (2016)
64. Effect of Inulin Supplementation in Male Mice Fed With High Fat Diet on Biochemical Profile and Α-Amylase Gene Expression, Tropical Journal of Pharmaceutical Research (2016)
65. Effect of Trans-Chalcone on Atheroma Plaque Formation, Liver Fibrosis and Adiponectin Gene Expression in Cholesterol-Fed Nmri Mice, Pharmacological Reports (2016)
66. Enhancing Activity and Thermostability of Lipase a From Serratia Marcescens by Site-Directed Mutagenesis, Enzyme and Microbial Technology (2016)
67. Molecular Investigation of Wfs1 Gene Exon 8 in Iranian Patients With Wolfram Syndrome, International Journal of Diabetes in Developing Countries (2016)
68. Neuroprotective Effects of Metformin Against Aβ-Mediated Inhibition of Long-Term Potentiation in Rats Fed a High-Fat Diet, Brain Research Bulletin (2016)
69. Acarbose Versus Transchalcone: Comparing the Effect of Two Glycosidase Inhibitors on Obese Mice, Archives of Endocrinology and Metabolism (2015)
70. Bacterial Expression and Characterization of an Active Recombinant Lipase a From Serratia Marcescens With Truncated C-Terminal Region, Journal of Molecular Catalysis B: Enzymatic (2015)
71. Cymene and Metformin Treatment Effect on Biochemical Parameters of Male Nmri Mice Fed With High Fat Diet, Journal of Diabetes and Metabolic Disorders (2015)
72. Effect of Cinnamomum Verum Extract on the Amyloid Formation of Hen Egg-White Lysozyme and Study of Its Possible Role in Alzheimer's Disease, Basic and Clinical Neuroscience (2015)
73. Effect of Neohesperidin Dihydrochalcone on the Activity and Stability of Alpha-Amylase: A Comparative Study on Bacterial, Fungal, and Mammalian Enzymes, Journal of Molecular Recognition (2015)
74. Inhibition of Amyloid Fibril Formation and Cytotoxicity by a Chemical Analog of Curcumin As a Stable Inhibitor, International Journal of Biological Macromolecules (2015)
75. Injection of Insulin Amyloid Fibrils in the Hippocampus of Male Wistar Rats: Report on Memory Impairment and Formation of Amyloid Plaques, Neurological Sciences (2015)
76. Rational Design of Stable and Functional Hirudin Iii Mutants With Lower Antigenicity, Biologicals (2015)
77. Segregation of a Novel Homozygous 6 Nucleotide Deletion in Glut2 Gene in a Fanconi-Bickel Syndrome Family, Gene (2015)
78. Structural and Dynamic Insight Into Hirudin Epitopes-Hla-Drb1 0101 Complexes and Their Modified Peptide Ligands: A Molecular Dynamic Simulation Study, Tropical Journal of Pharmaceutical Research (2015)
79. Structural Stability of Myoglobin and Glycomyoglobin: A Comparative Molecular Dynamics Simulation Study, Journal of Biological Physics (2015)
80. Thioflavin T Effect in Diabetic Wistar Rats: Reporting the Antihyperglycemic Property of an Amyloid Probing Dye, Pharmacological Reports (2015)
81. Uv Spectrophotometric Determination and Validation of Hydroquinone in Liposome, Iranian Journal of Pharmaceutical Research (2015)