Isfahan University of Medical Sciences

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Faculty Members have conducted research related to the Hybrid Pharmacophore Design, Molecular Docking, Synthesis, and Biological Evaluation of Novel Aldimine-Type Schiff Base Derivatives As Tubulin Polymerization Inhibitor
Ghadamali Khodarahmi
Ghadamali Khodarahmi

Professor of Pharmaceutical Chemistry

Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences

Pharmaceutical Sciences Research Center

Isfahan University of Medical Sciences

All Documents
1. Design, Synthesis, Bioactivity Analyses, and Molecular Docking Study of Triazine-Tyrosine Based Derivatives As Drugs Like Fingolimod for Treatment of Multiple Sclerosis, Polycyclic Aromatic Compounds (2024)
2. Novel Triazine-Tyrosine Hybrids Containing Thiyazol or Pyridine Fragment As Anti-Multiple Sclerosis Agents: Design, Synthesis, Biological Evaluation, and Molecular Docking Study, Heliyon (2024)
3. Heat Shock Proteins and Cancer: The Foxm1 Connection, Biochemical Pharmacology (2023)
4. Novel N-Α-Amino Acid Spacer-Conjugated Phthalimide–Triazine Derivatives: Synthesis, Antimicrobial and Molecular Docking Studies, Amino Acids (2023)
5. Novel Nanoscale Vanillin Based Covalent Triazine Framework As a Novel Carrier for Sustained Release of Imatinib, Polymers for Advanced Technologies (2023)
6. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
7. Design and Synthesis of Some Novel Triazine-Tyrosine Hybrids As Potential Agents for the Treatment of Multiple Sclerosis, Research in Pharmaceutical Sciences (2022)
8. Evaluation of the Antinociceptive Effects of a Selection of Triazine Derivatives in Mice, Korean Journal of Pain (2022)
9. Identification of New Small Molecules As Dual Foxm1 and Hsp70 Inhibitors Using Computational Methods, Research in Pharmaceutical Sciences (2022)
10. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
11. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
12. Quinazolinone-Based Hybrids With Diverse Biological Activities: A Mini-Review, Journal of Research in Medical Sciences (2022)
13. Some Novel Hybrid Quinazoline-Based Heterocycles As Potent Cytotoxic Agents, Research in Pharmaceutical Sciences (2022)
14. The Art of Design in Azlactone-Benzoxazinone Chemistry, Docking Studies and in Vitro Cytotoxicity Evaluation, Australian Journal of Chemistry (2022)
15. Design, Synthesis, and Bio-Evaluation of New Isoindoline-1,3-Dione Derivatives As Possible Inhibitors of Acetylcholinesterase, Research in Pharmaceutical Sciences (2021)
16. Design, Synthesis, Biological Evaluation, and Molecular Docking Study on Triazine Based Derivatives As Anti-Inflammatory Agents, Journal of Molecular Structure (2021)
17. Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of Pyrazole-Benzofuran Hybrids As New Α-Glucosidase Inhibitor, Scientific Reports (2021)
18. Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of Pyrazole-Benzofuran Hybrids As New Α-Glucosidase Inhibitor, Scientific Reports (2021)
19. Synthesis and Cytotoxic Evaluation of Some Novel 3-[2-(2-Phenyl-Thiazol-4-Yl)-Ethyl] -3H-Pyrido [2,3-D]Pyrimidin-4-One Derivatives, Research in Pharmaceutical Sciences (2021)
20. Monastrol Derivatives: In Silico and in Vitro Cytotoxicity Assessments, Research in Pharmaceutical Sciences (2020)
21. Synthesis, Cytotoxic Evaluation, and Molecular Docking Studies of Some New 1, 3, 4-Oxadiazole-Based Compounds, Research in Pharmaceutical Sciences (2020)
22. Synthesis and Cytotoxic Evaluation of Novel Quinozalinone Derivatives With Substituted Benzimidazole in Position 3, Research in Pharmaceutical Sciences (2019)
23. Folic Acid Targeted Polymeric Micelles Based on Tocopherol Succinate-Pulluan As an Effective Carrier for Epirubicin: Preparation, Characterization and In-Vitro Cytotoxicity Assessment, Current Drug Delivery (2018)
24. Hybrid Pharmacophore Design, Molecular Docking, Synthesis, and Biological Evaluation of Novel Aldimine-Type Schiff Base Derivatives As Tubulin Polymerization Inhibitor, Chemistry and Biodiversity (2018)
25. Novel Ngr Anchored Pullulan Micelles for Controlled and Targeted Delivery of Doxorubicin to Hela Cancerous Cells, Iranian Polymer Journal (English Edition) (2018)
26. Synthesis and Characterization of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2018)
27. Synthesis and Cytotoxic Evaluation of Some Novel Diarylamide Possessing Quinoxalinedione Based on Sorafenib, Research in Pharmaceutical Sciences (2018)
28. Biological Evaluation, Docking and Molecular Dynamic Simulation of Some Novel Diaryl Urea Derivatives Bearing Quinoxalindione Moiety, Research in Pharmaceutical Sciences (2017)
29. Biologically Active Heterocyclic Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties: Synthesis, Characterization, Cytotoxic and Antibacterial Evaluation, Chemistry and Biodiversity (2017)
30. Dft Studies of Graphene-Functionalised Derivatives of Capecitabine, Zeitschrift fur Naturforschung - Section A Journal of Physical Sciences (2017)
31. Docking Study, Synthesis and Antimicrobial Evaluation of Some Novel 4-Anilinoquinazoline Derivatives, Research in Pharmaceutical Sciences (2017)
32. Poly (Ethylene-Co-Vinyl Alcohol)-Based Polymeric Thermo-Responsive Nanocarriers for Controlled Delivery of Epirubicin to Hepatocellular Carcinoma, Research in Pharmaceutical Sciences (2017)
33. Quantum Mechanical/Molecular Mechanical and Docking Study of the Novel Analogues Based on Hybridization of Common Pharmacophores As Potential Anti-Breast Cancer Agents, Research in Pharmaceutical Sciences (2017)
34. Synthesis, Characterization, Cytotoxic Screening, and Density Functional Theory Studies of New Derivatives of Quinazolin-4(3H)-One Schiff Bases, Research in Pharmaceutical Sciences (2017)
35. Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel Hybrids Based on Quinazolinone, Benzofuran and Imidazolium Moieties As Potential Cytotoxic and Antimicrobial Agents, Iranian Journal of Basic Medical Sciences (2017)
36. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
37. Novel Aldimine-Type Schiff Bases of 4-Amino-5-[(3,4,5-Trimethoxyphenyl)Methyl]-1,2,4-Triazole-3-Thione/Thiol: Docking Study, Synthesis, Biological Evaluation, and Anti-Tubulin Activity, Archiv der Pharmazie (2016)
38. Quinazolinone and Quinazoline Derivatives: Recent Structures With Potent Antimicrobial and Cytotoxic Activities, Research in Pharmaceutical Sciences (2016)
39. Thermosensitive Folic Acid-Targeted Poly (Ethylene-Co-Vinyl Alcohol) Hemisuccinate Polymeric Nanoparticles for Delivery of Epirubicin to Breast Cancer Cells, Iranian Polymer Journal (English Edition) (2016)
40. Benzofuran As a Promising Scaffold for the Synthesis of Antimicrobial and Antibreast Cancer Agents: A Review, Journal of Research in Medical Sciences (2015)
41. Cytotoxic Evaluation of Volatile Oil From Descurainia Sophia Seeds on Mcf-7 and Hela Cell Lines, Research in Pharmaceutical Sciences (2015)
42. Design of Novel Potential Aromatase Inhibitors Via Hybrid Pharmacophore Approach: Docking Improvement Using the Qm/Mm Method, RSC Advances (2015)
43. Synthesis of Some New Porphyrins and Their Metalloderivatives As Potential Sensitizers in Photo-Dynamic Therapy, Research in Pharmaceutical Sciences (2015)
44. Formulation and Evaluation of Triamcinolone Acetonide Mucoadhesive Film As Treatment of Aphthous Stomatitis and Oral Inflammatory Diseases, Journal of Isfahan Medical School (2013)
45. Antibacterial, Antifungal and Cytotoxic Evaluation of Some New 2,3-Disubstituted 4(3H)-Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
46. Antibacterial, Antifungal and Cytotoxic Evaluation of Some New Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
47. Genotoxic Effects of Some L-[(Benzofuran-2-Yl)-Phenylmethyl]-Imidazoles on Mcf-7 Cell Line, Research in Pharmaceutical Sciences (2012)
48. Synthesis and Cytotoxic Evaluation of Some New 4(3H)-Quinazolinones on Hela Cell Line, Research in Pharmaceutical Sciences (2012)
49. Synthesis and Evaluation of the Anxiolytic Activity of Some Phthalimide Derivatives in Mice Model of Anxiety, Iranian Journal of Pharmaceutical Research (2012)
50. Synthesis of Some New 2,3-Disubstituted-4(3H)Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2012)
51. Cytotoxic Effects of Different Extracts and Latex of Ficus Carica L. on Hela Cell Line, Iranian Journal of Pharmaceutical Research (2011)
52. Synthesis of Some New Tricyclic 4(3H)-Quinazolinone Derivatives, Research in Pharmaceutical Sciences (2011)
53. Design, Synthesis, and Antibacterial Activity of Novel Carbacephems, Letters in Drug Design and Discovery (2006)
54. Carbapenem-Based Prodrugs. Design, Synthesis, and Biological Evaluation of Carbapenems, European Journal of Medicinal Chemistry (2005)
55. Synthesis and Primary Cytotoxic Screening of Some 3-Sulfonamide Substituted Benzamido-Benzimidazolones, Iranian Journal of Pharmaceutical Research (2005)
56. Application of the Barton Photochemical Reaction in the Synthesis of 1-Dethia-3-Aza-1-Carba-2-Oxacephem: A Novel Agent Against Resistant Pathogenic Microorganisms, Organic and Biomolecular Chemistry (2003)
57. Design, Synthesis, and Anticancer Activity of Phosphonic Acid Diphosphate Derivative of Adenine-Containing Butenolide and Its Water-Soluble Derivatives of Paclitaxel With High Antitumor Activity, Bioorganic and Medicinal Chemistry (2003)