Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Sciatic Nerve Regeneration With Collagen Type I Hydrogel Containing Chitosan Nanoparticle Loaded by Insulin Publisher



Ai A1 ; Behforouz A1 ; Ehterami A2 ; Sadeghvaziri N1 ; Jalali S1 ; Farzamfar S3 ; Yousefbeigi A1 ; Ai A1 ; Goodarzi A3 ; Salehi M5, 6 ; Ai J3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dental Student of Scientific Research Center, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  6. 6. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2019


Abstract

The current study was conducted to promote the extent of peripheral nerve regeneration using a collagen type I hydrogel containing chitosan nanoparticle loaded by insulin. The developed hydrogel increased the proliferation rate of Schwann cells as shown by tetrazolium salt-based assay. For functional analysis, the hydrogel was administrated in the sciatic nerve crush injury of Wistar rats. The results of the sciatic functional index, hot plate latency, compound muscle action potential amplitude and weight-loss percentage of the wet gastrocnemius muscle, indicated that the prepared hydrogel could be considered as a potential material for peripheral nerve regeneration. © 2018, © 2018 Taylor & Francis Group, LLC.
Related Docs
View other Related Docs
1. Regeneration of Sciatic Nerve Crush Injury by a Hydroxyapatite Nanoparticle-Containing Collagen Type I Hydrogel, Journal of Physiological Sciences (2018)
2. Enhanced Sciatic Nerve Regeneration With Fibrin Scaffold Containing Human Endometrial Stem Cells and Insulin Encapsulated Chitosan Particles: An in Vivo Study, Injury (2023)
3. Naturally Occurring Biological Macromolecules-Based Hydrogels: Potential Biomaterials for Peripheral Nerve Regeneration, International Journal of Biological Macromolecules (2020)
4. Sciatic Nerve Regeneration by Using Collagen Type I Hydrogel Containing Naringin, Journal of Materials Science: Materials in Medicine (2019)
5. Regeneration of Sciatic Nerve Injury Through Nanofiber Neural Guidance Channels Containing Collagen Hydrogel and Acetyl L Carnitine: An in Vitro and in Vivo Study, Journal of Bioactive and Compatible Polymers (2023)
6. Prospects of Peripheral Nerve Tissue Engineering Using Nerve Guide Conduits Based on Silk Fibroin Protein and Other Biopolymers, International Materials Reviews (2017)
7. In Vitro and in Vivo Study of Pcl/Coll Wound Dressing Loaded With Insulin-Chitosan Nanoparticles on Cutaneous Wound Healing in Rats Model, International Journal of Biological Macromolecules (2018)
8. Preparation of Bilayer Tissue-Engineered Polyurethane/Poly-L-Lactic Acid Nerve Conduits and Their in Vitro Characterization for Use in Peripheral Nerve Regeneration, Journal of Biological Engineering (2024)
Experts (# of related papers)
View all Related Experts
Somayeh Ebrahimi Barough (4)
Zahra Hassannejad (1)
Other Related Docs
9. Fabrication and in Vitro Evaluation of 3D Composite Scaffold Based on Collagen/Hyaluronic Acid Sponge and Electrospun Polycaprolactone Nanofibers for Peripheral Nerve Regeneration, Journal of Biomedical Materials Research - Part A (2021)
10. Unrestricted Somatic Stem Cells Loaded in Nanofibrous Conduit As Potential Candidate for Sciatic Nerve Regeneration, Journal of Molecular Neuroscience (2019)
11. Tissue-Engineered Nerve Graft Using Silk-Fibroin/Polycaprolactone Fibrous Mats Decorated With Bioactive Cerium Oxide Nanoparticles, Journal of Biomedical Materials Research - Part A (2021)
12. Bridging Potential of Taurine-Loading Pcl Conduits Transplanted With Henscs on Resected Sciatic Nerves, Regenerative Therapy (2022)
13. In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications, Artificial Cells# Nanomedicine and Biotechnology (2018)
14. A Novel Polycaprolactone/Carbon Nanofiber Composite As a Conductive Neural Guidance Channel: An in Vitro and in Vivo Study, Progress in Biomaterials (2019)
15. Design and Fabrication of a Nanofibrous Polycaprolactone Tubular Nerve Guide for Peripheral Nerve Tissue Engineering Using a Two-Pole Electrospinning System, Biomedical Materials (Bristol) (2016)
16. Neural Tissue Regeneration by a Gabapentin-Loaded Cellulose Acetate/Gelatin Wet-Electrospun Scaffold, Cellulose (2018)
17. Sciatic Nerve Regeneration by Transplantation of Menstrual Blood-Derived Stem Cells, Molecular Biology Reports (2017)