Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chitosan/Alginate Hydrogels Containing Alpha-Tocopherol for Wound Healing in Rat Model Publisher



Ehterami A1 ; Salehi M2, 3 ; Farzamfar S4 ; Samadian H5 ; Vaez A4 ; Ghorbani S6 ; Ai J4 ; Sahrapeyma H7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  4. 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  7. 7. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2019


Abstract

The skin tissue engineering has emerged as an alternative to conventional treatment of skin injuries. Three-dimensional (3D) hydrogels-based scaffolds are promising and widely used for this purpose. Considering the high performance of alginate, chitosan and Alpha-tocopherol (vitamin E) in the skin tissue engineering, we evaluate the potential of this vitamin E-loaded hydrogel for the healing of the dorsal skin injury in a rat model. In this research, porous cross-linked Chit/Alg hydrogels containing Alpha-tocopherol (Vitamin E) were fabricated and their morphology, swelling properties, weight loss, hemo- and cytocompatibility were evaluated. Finally, the therapeutic function of the developed hydrogels was studied in the full-thickness dermal wound model. Our data showed that the produced hydrogel was highly porous, the porosity of 89.2 ± 12.5%, with the interconnected pores. Weight loss assessment showed that the prepared hydrogel is biodegradable with the weight loss percentage of about 80% in 14 days. Also, the results showed that the prepared hydrogel-based dressings had the higher wound closure than the gauze-treated wound (the control) and the highest wound closure percentage was obtained with the Chit/Alg/400 IU Vit E group. All in all, this study suggests that 3D Chit/Alg hydrogels with 400 IU Vit E can be used to treat the skin injuries in the clinic. © 2019 Elsevier B.V.
Related Docs
View other Related Docs
1. Kaolin-Loaded Chitosan/Polyvinyl Alcohol Electrospun Scaffold As a Wound Dressing Material: In Vitro and in Vivo Studies, Journal of Wound Care (2020)
2. Accelerating Healing of Excisional Wound With Alginate Hydrogel Containing Naringenin in Rat Model, Drug Delivery and Translational Research (2021)
3. Study of Hybrid Alginate/Gelatin Hydrogel-Incorporated Niosomal Aloe Vera Capable of Sustained Release of Aloe Vera As Potential Skin Wound Dressing, Polymer Bulletin (2020)
4. In Vitro and in Vivo Study of Pcl/Coll Wound Dressing Loaded With Insulin-Chitosan Nanoparticles on Cutaneous Wound Healing in Rats Model, International Journal of Biological Macromolecules (2018)
5. A Promising Wound Dressing Based on Alginate Hydrogels Containing Vitamin D3 Cross-Linked by Calcium Carbonate/D-Glucono-Δ-Lactone, Biomedical Engineering Letters (2020)
6. Alginate-Gelatin Composite Hydrogels Loading Zeolitic Imidazolate Framework-8 (Zif-8) Nanoparticles on Gauze for Burn Wound Healing: In Vitro and in Vivo Studies, International Journal of Biological Macromolecules (2025)
7. Cellulose Acetate/Plerixafor Wound Dressings for Transplantation of Menstrual Blood Stem Cells: Potential Treatment Modality for Diabetic Wounds, Journal of Drug Delivery Science and Technology (2022)
8. Erythropoietin/Aloe Vera-Releasing Wet-Electrospun Polyvinyl Alcohol/Chitosan Sponge-Like Wound Dressing: In Vitro and in Vivo Studies, Journal of Bioactive and Compatible Polymers (2018)
Experts (# of related papers)
View all Related Experts
Mahmoud Azami (3)
Reza Faridi Majidi (3)
Other Related Docs
9. Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration, Advances in Experimental Medicine and Biology (2018)
10. Antibacterial and Antioxidant Assessment of Cellulose Acetate/Polycaprolactone Nanofibrous Mats Impregnated With Propolis, International Journal of Biological Macromolecules (2019)
11. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
12. Chitosan-Grafted Graphene Materials for Drug Delivery in Wound Healing, Current Pharmaceutical Design (2025)
13. Fabrication and Evaluation of Chitosan/Gelatin/Pva Hydrogel Incorporating Honey for Wound Healing Applications: An in Vitro, in Vivo Study, International Journal of Pharmaceutics (2021)
14. Review: The Latest Advances in Biomedical Applications of Chitosan Hydrogel As a Powerful Natural Structure With Eye-Catching Biological Properties, Journal of Materials Science (2022)
15. Encapsulation of Cartilage Cells, Principles of Biomaterials Encapsulation: Volume 2 (2023)
16. The Single and Synergistic Effects of Montmorillonite and Curcumin-Loaded Chitosan Microparticles Incorporated Onto Poly(Lactic Acid) Electrospun Film on Wound-Healing, Journal of Bioactive and Compatible Polymers (2018)
17. Various Parameters in the Preparation of Chitosan/Polyethylene Oxide Electrospun Nanofibers Containing Aloe Vera Extract for Medical Applications, Nanomedicine Journal (2020)
18. Cartilage Tissue Engineering by Co-Transplantation of Chondrocyte Extracellular Vesicles and Mesenchymal Stem Cells, Entrapped in Chitosan-Hyaluronic Acid Hydrogel, Biomedical Materials (Bristol) (2021)
19. Scaffolds for Gingival Tissues, Handbook of Tissue Engineering Scaffolds: Volume One (2019)
20. Design and Optimization of Thermosensitive Injectable Alginate-Based Hydrogels: Potential for Loading Therapeutic Compounds, Iranian Polymer Journal (English Edition) (2025)
21. Evaluation of Effective Needleless Electrospinning Parameters Controlling Polyacrylonitrile Nanofibers Diameter Via Modeling Artificial Neural Networks, Journal of the Textile Institute (2019)
22. Novel Wound Dressing Based on Postbiotic/Chitosan Film Accelerates Cutaneous Wound Healing, Jundishapur Journal of Microbiology (2021)
23. Natural Product-Based Nanomedicines for Wound Healing Purposes: Therapeutic Targets and Drug Delivery Systems, International Journal of Nanomedicine (2018)
24. Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine, Advances in Experimental Medicine and Biology (2018)
25. Can Regenerative Medicine and Nanotechnology Combine to Heal Wounds? the Search for the Ideal Wound Dressing, Nanomedicine (2017)
26. Biological Macromolecule-Based Scaffolds for Urethra Reconstruction, Biomolecules (2023)
27. In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications, Artificial Cells# Nanomedicine and Biotechnology (2018)
28. Bi-Layered Photocrosslinkable Chitosan-Curcumin Hydrogel/Soy Protein Nanofibrous Mat Skin Substitute, Materialia (2023)
29. Hybrid Pcl/Chitosan-Peo Nanofibrous Scaffolds Incorporated With A. Euchroma Extract for Skin Tissue Engineering Application, Carbohydrate Polymers (2022)
30. Electroactive Nanofibrous Scaffold Based on Polythiophene for Bone Tissue Engineering Application, Journal of Materials Research (2022)
31. Dextran Hydrogels Incorporated With Bioactive Glass-Ceramic: Nanocomposite Scaffolds for Bone Tissue Engineering, Carbohydrate Polymers (2018)
32. Adipose Tissue-Derived Stromal Cells for Wound Healing, Advances in Experimental Medicine and Biology (2018)
33. Neural Tissue Regeneration by a Gabapentin-Loaded Cellulose Acetate/Gelatin Wet-Electrospun Scaffold, Cellulose (2018)
34. Current Advances in Wound Healing and Regenerative Medicine, Current Stem Cell Research and Therapy (2024)
35. Hydrogels As Intelligent Materials: A Brief Review of Synthesis, Properties and Applications, Materials Today Chemistry (2018)
36. The Effect of Alpha-Tocopherol on the Expression of Epidermal Growth Factor Receptor and Transforming Growth Factor Beta Genes in Three Developmental Stages of Echinococcus Granulosus, Iranian Journal of Parasitology (2020)
37. Fabrication Technology of Chitosan-Based Ipn: Drug Delivery Application, Interpenetrating Polymer Network: Biomedical Applications (2020)
38. Taurine-Loaded Poly (Ε-Caprolactone)/Gelatin Electrospun Mat As a Potential Wound Dressing Material: In Vitro and in Vivo Evaluation, Journal of Bioactive and Compatible Polymers (2018)
39. Application of Chitosan in Oral Drug Delivery, Functional Chitosan: Drug Delivery and Biomedical Applications (2020)