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Recent Progress in Transformations of Azepine/Oxazepine/Thiazepine Derivatives Publisher



Doraghi F1 ; Ameli M2 ; Karimian S3 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  3. 3. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: ChemistrySelect Published:2024


Abstract

Dibenzoazepine, dibenzoxazepine and dibenzothiazepine scaffolds are an important class of N-heterocycles that possess multiple biological activities. Due to the widespread application of these motifs in drug discovery, the synthesis of tri-cyclic seven-membered imines/amines has gained huge attention of chemists. In the present review, we have highlighted recent advances in functionalization and cyclization reactions of these valuable organic compounds over the last six years. © 2024 Wiley-VCH GmbH.