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Activation and Deactivation of 5-Ht1 Receptor of Accumbens Shell Area Does Not Alter Acpa-Induced Aversive Memory Deficit in Male Rat Pubmed



Keramatinojedehsadat M1 ; Oryan S2 ; Zarrindast MR3, 4 ; Babapour V5
Authors
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Authors Affiliations
  1. 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Biology, Faculty of Basic Science, Kharazmi University, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  5. 5. Department of Physiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

Source: Archives of Iranian Medicine Published:2017


Abstract

Background: Some studies have indicated a close relation between serotonergic and cannabinoidergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male Wistar rats. Methodology: Bilateral guide cannulae were implanted to allow microinjection of ACPA, CP94253 Hcl (5-HT1 receptor agonist agonist) orGR127935 Hcl (5-HT1 receptorantagonist). Results: Post-test intra-Acb shell of ACPA (0.002 µg/rat), CP94253 (0.5 and 5 ng/rat) and GR127935 (5 ng/rat) increased the percentage of open-arms time (%OAT) in the EPM task compared to the control group, indicating aversive memory deficit. Moreover, concurrent microinjection of the subthreshold dose of CP94253 and GR127935 into Acb shell did not alter open-arms exploratory behavior induced by intra-Acb shell of ACPA on the retest day. Conclusion: Our data suggests that Acb shell 5-HT1 receptor does not affect aversive memory deficit induced by ACPA in the Acb shell. © 2017, Academy of Medical Sciences of I.R. Iran. All rights reserved.
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