Magnetically Lung Tissue Targeting Using Electrosprayed Nano-In-Micro Alginate Based Antibiotic Composed of Amphotericin B and Magnetic Quantum Dots Publisher



H Veisi HAMED ; S Hosseinzadeh SIMZAR ; Sm Rezayat Sorkhabadi Seyed MAHDI
Source: Inorganic Chemistry Communications Published:2025

Abstract

Invasive Fungal pulmonary infections caused by opportunistic pathogens pose as significant therapeutic challenges due to the limited efficacy and systemic toxicity of conventional antifungal therapies. This study presents a novel approach for targeted pulmonary drug delivery on Candida albicans and Aspergillus fumigatus as lung infection model. Magnetic quantum dots (Zn0.5 Co0.5 Fe2O4) synthesized by co-precipitation chemical method in hydrothermal condition at rang of quantum dots nearly less than 10 nm. nanoparticles (15 w/w), low molecular weight alginate salt (80 w/w) and amphotericin B (5 w/w); Then suspension was sprayed under a high voltage of 25 kV at a flow rate of 0.4 mL/min. reach a powder in 1–2 µm size is key factor in pulmonary drug delivery. This carriers leverage the dual benefits of controlled drug release and targeting to enhance therapeutic efficacy and reduce systemic side effects. Comprehensive physicochemical characterization revealed the carriers’ spherical morphology, crystalline integrity, and superparamagnetic behavior, as confirmed by TEM, SEM, XRD, and VSM analyses. The carriers demonstrated sustained AmB release over 72 h, as evidenced by UV–Vis spectroscopy, achieving first explosive therapeutic drug availability. Antifungal evaluations showed that the system effectively inhibited the growth with a minimum inhibitory concentration (MIC) of 30 µg/mL: according to clinical and laboratory standards institute (CLSI). Cytotoxicity assays indicated significantly enhanced biocompatibility compared to free AmB, attributed to the protective alginate matrix. In vivo analysis using ICP-OES demonstrated superior localization of magnetic nanoparticles in magnetically targeted lung tissues, underscoring the platform's potential for precision medicine applications. The integration of biocompatible alginate and magnetic nanoparticles offers a transformative solution for addressing the challenges of antifungal therapy. This platform not only enhances drug targeting and therapeutic efficacy but also aligns with the principles of precision medicine, paving the way for safer and more effective treatments for pulmonary fungal infections. © 2025 Elsevier B.V., All rights reserved.