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Dietary Anthocyanins As a Complementary Medicinal Approach for Management of Inflammatory Bowel Disease Publisher Pubmed



Sodagari HR1 ; Farzaei MH2, 3 ; Bahramsoltani R3, 4 ; Abdolghaffari AH5, 6 ; Mahmoudi M7 ; Rezaei N8, 9, 10
Authors
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Authors Affiliations
  1. 1. Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
  2. 2. Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  3. 3. Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, 1417653761, Iran
  4. 4. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pharmacology and Applied Medicine Department, Medicinal Plants Research Center, Institute of Medicinal Plants, Karaj, Iran
  6. 6. International Campus, ICTUMS, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Keshavarz Blvd, Tehran, 14194, Iran
  9. 9. Molecular Immunology Research Center, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom

Source: Expert Review of Gastroenterology and Hepatology Published:2015


Abstract

Inflammatory bowel disease (IBD) is thought to result from a chronic or relapsing activation of the immune system in the GI tract. A growing body of evidence confirms the health benefits of dietary anthocyanins as plant-derived natural agents. The aim of this review is to provide an overview of several natural products rich in anthocyanins used worldwide for the treatment of IBD. Anthocyanins possess both protective and therapeutic functions in the management of IBD by alleviating oxidative stress processes, cytoprotective functions, downregulation of inflammatory cytokines and suppressing cellular signaling pathways of inflammatory processes. In conclusion, the consumption of anthocyanin-rich natural formulations must be promoted on the basis of their possible function in the prevention and treatment of gastrointestinal inflammatory disorders. © 2015 Informa UK, Ltd.
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