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Sex Differences in Stroke Incidence, Prevalence,Mortality and Disability-Adjusted Life Years: Results From the Global Burden of Disease Study 2013 Publisher Pubmed



Barkercollo S1 ; Bennett DA3 ; Krishnamurthi RV2 ; Parmar P2 ; Feigin VL2 ; Naghavi M4 ; Forouzanfar MH5 ; Johnson CO5 ; Nguyen G5 ; Mensah GA7 ; Vos T4 ; Murray CJL4 ; Roth GA5, 6 ; Abdallah F8 Show All Authors
Authors
  1. Barkercollo S1
  2. Bennett DA3
  3. Krishnamurthi RV2
  4. Parmar P2
  5. Feigin VL2
  6. Naghavi M4
  7. Forouzanfar MH5
  8. Johnson CO5
  9. Nguyen G5
  10. Mensah GA7
  11. Vos T4
  12. Murray CJL4
  13. Roth GA5, 6
  14. Abdallah F8
  15. Abera SF9
  16. Akinyemi RO10
  17. Bahit MC11
  18. Banerjee A12
  19. Basu S13
  20. Brainin M14
  21. Bornstein NM15
  22. Caso V16
  23. Catalalopez F17
  24. Chowdhury R18
  25. Christensen HK19
  26. Colomar M20
  27. Davis S21
  28. Deveber G22
  29. Dharmaratne SD23
  30. Donnan G24
  31. Dorairaj P25
  32. Dokova K26
  33. Endres M27
  34. Fernandes JG28
  35. Geleijnse JM29
  36. Gillum RF30
  37. Giroud M31
  38. Hamadeh RR32
  39. Hankey GJ33
  40. Jeemon P34
  41. Jiang G35
  42. Jonas JB36
  43. Kalkonde Y37
  44. Kengne AP38
  45. Kim D39
  46. Kissela BM40
  47. Kokubo Y41
  48. Lavados PM42
  49. Patrice Lindsay M43
  50. Lotufo PA44
  51. Mackay MT45
  52. Malekzadeh R46
  53. Mehndiratta MM47
  54. Nand D48
  55. Norrving B49
  56. Pandian JD50
  57. Perkins H51
  58. Pourmalek F52
  59. Ricci S53
  60. Riccio PM54
  61. Rojasrueda D55
  62. Roy N56
  63. Sacco RL57
  64. Sahathevan R58, 72
  65. Sheth KN59
  66. Shiue I60
  67. Sposato LA61
  68. Tanne D62
  69. Thrift AG63
  70. Thurston GD64
  71. Tirschwell DL65
  72. Venketasubramanian N66
  73. Vlassov VV67
  74. Westerman R68
  75. Wolfe C69, 70
  76. Yunjin K71
  77. Meretoja A73
  78. Stavreski B73
  79. Anderson CS73
  80. Pearse E73
  81. Ademi Z73
  82. Guliyev T74
  83. Harewood H75
  84. Springer K75
  85. Da Costa Leite I76
  86. Cabral NL76
  87. Li B77
  88. Yu C77
  89. Ma J77
  90. Zhou M77
  91. Liu M77
  92. Zhu S77
  93. Wang W77
  94. Liang X77
  95. Zhang Y77
  96. Alcalacerra G78
  97. Truelsen T79
  98. Temesgen A80
  99. Sahle BW80
  100. Melaku YA80
  101. Stroumpoulis K81
  102. Prabhakaran D82
  103. Gupta R82
  104. Rajagopalan V82
  105. Kosen S83
  106. Warouw TS83
  107. Odonnell MJ85
  108. Shinohara Y86
  109. Asad MM87
  110. Bwire VK88
  111. Jee SH89
  112. Khang YH89
  113. Camposnonato I91
  114. Gankpe F92
  115. Myint CY93
  116. Norheim O95
  117. Khalifa SE96
  118. Kravchenko M97
  119. Piradov M97
  120. Shalamov N97
  121. Varakin Y97
  122. De Dieu Ngirabega J98
  123. Nyemazi JP98
  124. Muhimpundu MA98
  125. Saeedi M99
  126. Bedi N99
  127. Havmoeller R100
  128. Atwine L101
  129. Ocallaghan F102
  130. Critchley JA102
  131. Ezzati M102
  132. Soljak M102
  133. Connor MD102
  134. Rothwell PM102
  135. Salman RAS102
  136. Whiteley W102
  137. Chen Z102
  138. Durrani AM103
  139. Dayama A103
  140. Moran AE103
  141. Misganaw A103
  142. Amlielefond C103
  143. Huang C103
  144. Sumeet C103
  145. Cundiff DK103
  146. Kazi DS103
  147. Qato D103
  148. Kabagambe EK103
  149. Ding E103
  150. Bukhman G103
  151. Kwan G103
  152. Coresh J103
  153. Lefondulq K103
  154. Corriere MA103
  155. Mainoo N103
  156. Beauchamp NJ103
  157. Schwartz SM103
  158. Chugh S103
  159. Fung T103
  160. Byers TE103
  161. Sampson UKA103
  162. Rocca WA103
  163. Lo W103
Show Affiliations
Authors Affiliations
  1. 1. School of Psychology, The University of Auckland, New Zealand
  2. 2. National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies, AUT University, Auckland, New Zealand
  3. 3. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  4. 4. Department of Global Health, School of Medicine and Public Health, University of Washington, Seattle, WA, United States
  5. 5. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States
  6. 6. Division of Cardiology, School of Medicine, University of Washington, Seattle, WA, United States
  7. 7. Center for Translation Research and Implementation Science and Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States
  8. 8. Department of Neurology, Cairo University, Cairo, Egypt
  9. 9. Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
  10. 10. Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
  11. 11. Department of Cardiology INECO Neurociencias Orono, Rosario, Santa Fe, Argentina
  12. 12. Farr Institute of Health Informatics Research, University College London, London, United Kingdom
  13. 13. School of Medicine, Stanford University, Stanford, CA, United States
  14. 14. Department of Clinical Neurology, Danube University Krems and Karl Landsteiner University, Krems, Austria
  15. 15. Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  16. 16. Stroke Unit, University of Perugia, Perugia, Italy
  17. 17. Department of Medicine, University of Valencia, Valencia, Spain
  18. 18. Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
  19. 19. University of Copenhagen and Bispebjerg Hospital, Denmark
  20. 20. Unidad de Investigacion Clinica y Epidemiologica Montevideo, Uruguay
  21. 21. University of Melbourne Parkville, Australia
  22. 22. Division of Neurology Hospital for Sick Children Senior Scientist, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
  23. 23. Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Institute for Health Metrics and Evaluation, Department of Global Health, School of Public Health, University of Washington, Washington, United States
  24. 24. The Florey Institute of Neuroscience and Mental Health and School of Neurology, University of Melbourne, Melbourne, Australia
  25. 25. Centre for Chronic Conditions and Injuries and Public Health Foundation of India, Delhi, India
  26. 26. Department of Social Medicine and Health Care Organization, Faculty of Public Health, Medical University of Varna, Varna, Bulgaria
  27. 27. Klinik und Hochschulambulanz fur Neurologie, Charite-Universitatsmedizin Berlin, Germany
  28. 28. School of Health Education and Sciences German Hospital Oswaldo Cruz Sao Paulo, Brazil
  29. 29. Division of Human Nutrition/Epidemiology, Wageningen University, Netherlands
  30. 30. Department of Internal Medicine and Department of Community and Family Medicine, Howard University College of Medicine, Washington, United States
  31. 31. Dijon Stroke Registry, Service de Neurologie, Dijon, France
  32. 32. Department of Family and Community Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Bahrain
  33. 33. School of Medicine and Pharmacology, The University of Western Australia, Australia
  34. 34. Centre for Control of Chronic Conditions, Public Health Foundation of India and Centre for Chronic Disease Control, New Delhi, India
  35. 35. Tianjin Centers for Diseases Control and Prevention, School of Public Health, Tianjin Medical University, and School of Public Health, Tongji Medical University, Hubei, China
  36. 36. Department of Ophthalmology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
  37. 37. Society for Education, Action and Research in Community Health, District of Gadchiroli, India
  38. 38. South African Medical Research Council, Francie van Zijl Drive, Parrow Valley, Cape Town, South Africa
  39. 39. Department of Health Sciences, Northeastern University, Boston, United States
  40. 40. Department of Neurology and Rehabilitation Medicine, University of Cincinnati, United States
  41. 41. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
  42. 42. Servicio de Neurologia, Departamento de Medicina, Clinica Alemana de Santiago-Universidad del Desarrollo, Santiago, Chile
  43. 43. Stroke Heart and Stroke Foundation, Fondation des maladies du coeur et de l’AVC, ON, Canada
  44. 44. Centre for Clinical and Epidemiological Research, University of Sao Paulo, Sao Paulo, Brazil
  45. 45. Department of Neurology, Royal Children’s Hospital Melbourne and Murdoch Children’s Research Institute, Parkville, Australia
  46. 46. Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran
  47. 47. Janakpuri Super Speciality Hospital, New Delhi, India
  48. 48. Health Information Unit, Dinem Hous, Toorak, Suva, Fiji
  49. 49. Department of Clinical Sciences, Lund University, Sweden
  50. 50. Department of Neurology Christian Medical College, Ludhiana, Punjab, India
  51. 51. Institute of Medical Research, QEII Medical Centre, Perth, Australia
  52. 52. School of Population and Public Health, University of British Columbia, Canada
  53. 53. UO Nurologia, Umbria edi di Citta di Castello e Branca, Italy
  54. 54. Department of Clinical Neurological Sciences, Londonde Health Sciences Centre, Western University, London, Canada
  55. 55. Centre for Research in Environmental Epidemiology, ISGlobal, Barcelona, Spain
  56. 56. Environmental health resource hub, School of Habitat studies, Tata Institute of Social sciences, Mumbai, India
  57. 57. University of Miami Miller School of Medicine, Department of Neurology, Miami, FL, United States
  58. 58. Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur, Malaysia
  59. 59. Division of Neurocritical Care and Emergency Department of Neurology Neurosciences Intensive Care Unit, Yale School of Medicine and Yale New Haven Hospital, New York, United States
  60. 60. Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom
  61. 61. Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada
  62. 62. Chaim Sheba Medical Center, Tel-Aviv University, Israel
  63. 63. Stroke and Ageing Research (STARC), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
  64. 64. Department of Population Health and Environmental Medicine, Tuxedo, NY, United States
  65. 65. University of Washington School of Medicine, UW Medicine Comprehensive Stroke Center, Harborview Medical Center, Seattle, WA, United States
  66. 66. Raffles Neuroscience Centre, Raffles Hospital, Singapore
  67. 67. National Research University Higher School of Economics, Moscow, Russian Federation
  68. 68. Competence Center Mortality-Follow-Up of the German National Cohort, Federal Institute for Population Research, Wiesbaden, Germany
  69. 69. Division of Health and Social Care Research, King’s College London, London, United Kingdom
  70. 70. National Institute for Health Research Comprehensive Biomedical Research Centre, Guy’s and St., Thomas’ NHS Foundation Trust and King’s College London, London, United Kingdom
  71. 71. Faculty of Chinese Medicine Southern University College, Johor, Malaysia
  72. 72. Calvary Healthcare Bruce, ACT, Australia
  73. 73. Australia
  74. 74. Azerbaijan
  75. 75. Barbados
  76. 76. Brazil
  77. 77. China
  78. 78. Colombia
  79. 79. Denmark
  80. 80. Ethiopia
  81. 81. Greece
  82. 82. India
  83. 83. Indonesia
  84. 84. Iran
  85. 85. Ireland
  86. 86. Japan
  87. 87. Jordan
  88. 88. Kenya
  89. 89. South Korea
  90. 90. Malaysia
  91. 91. Mexico
  92. 92. Morocco
  93. 93. Myanmar
  94. 94. New Zealand
  95. 95. Norway
  96. 96. Qatar
  97. 97. Russian Federation
  98. 98. Rwanda
  99. 99. Saudi Arabia
  100. 100. Sweden
  101. 101. Uganda
  102. 102. United Kingdom
  103. 103. United States

Source: Neuroepidemiology Published:2015


Abstract

Background: Accurate information on stroke burden in men and women are important for evidence-based healthcare planning and resource allocation. Previously, limited research suggested that the absolute number of deaths from stroke in women was greater than in men, but the incidence and mortality rates were greater in men. However, sex differences in various metrics of stroke burden on a global scale have not been a subject of comprehensive and comparable assessment for most regions of the world, nor have sex differences in stroke burden been examined for trends over time. Methods: Stroke incidence, prevalence, mortality, disability-adjusted life years (DALYs) and healthy years lost due to disability were estimated as part of the Global Burden of Disease (GBD) 2013 Study. Data inputs included all available information on stroke incidence, prevalence and death and case fatality rates. Analysis was performed separately by sex and 5-year age categories for 188 countries. Statistical models were employed to produce globally comprehensive results over time. All rates were age-standardized to a global population and 95% uncertainty intervals (UIs) were computed. Findings: In 2013, global ischemic stroke (IS) and hemorrhagic stroke (HS) incidence (per 100,000) in men (IS 132.77 (95% UI 125.34-142.77); HS 64.89 (95% UI 59.82-68.85)) exceeded those of women (IS 98.85 (95% UI 92.11-106.62); HS 45.48 (95% UI 42.43-48.53)). IS incidence rates were lower in 2013 compared with 1990 rates for both sexes (1990 male IS incidence 147.40 (95% UI 137.87-157.66); 1990 female IS incidence 113.31 (95% UI 103.52-123.40)), but the only significant change in IS incidence was among women. © 2015 S. Karger AG, Basel.