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T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders Publisher Pubmed



Mirshafiey A1 ; Simhag A2 ; El Rouby NMM3 ; Azizi G4, 5
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Karolinska Institutet Science Park AB, Huddinge, Sweden
  3. 3. Department of Histology, Dubai Medical College, Dubai, United Arab Emirates
  4. 4. Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Dermatology Published:2015


Abstract

T-helper 22 (Th22) cell is a new subset of CD4+ T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-γ. Th22 is distinct from Th17 and other known CD4+ T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6+ CCR4+ CCR10+ phenotype and aryl hydrocarbon receptor as the key transcription factor. This T-helper subset, by producing cytokines such as IL-22, IL-13, and tumor necrosis factor-α, is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis. © 2015 The International Society of Dermatology.
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