T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders

T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders Publisher Pubmed

Mirshafiey A¹ ; Simhag A² ; El Rouby NMM³ ; Azizi G^{4, 5}

Source: International Journal of Dermatology Published:2015

Abstract

T-helper 22 (Th22) cell is a new subset of CD4+ T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-γ. Th22 is distinct from Th17 and other known CD4+ T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6+ CCR4+ CCR10+ phenotype and aryl hydrocarbon receptor as the key transcription factor. This T-helper subset, by producing cytokines such as IL-22, IL-13, and tumor necrosis factor-α, is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis. © 2015 The International Society of Dermatology.

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Maryam Izad (1)

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Style	Citing Format
MLA	Mirshafiey A, et al.. "T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders." International Journal of Dermatology, vol. 54, no. 8, 2015, pp. 880-888.
APA	Mirshafiey A, Simhag A, El Rouby NMM, Azizi G (2015). T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders. International Journal of Dermatology, 54(8), 880-888.
Chicago	Mirshafiey A, Simhag A, El Rouby NMM, Azizi G. "T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders." International Journal of Dermatology 54, no. 8 (2015): 880-888.
Harvard	Mirshafiey A et al. (2015) 'T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders', International Journal of Dermatology, 54(8), pp. 880-888.
Vancouver	Mirshafiey A, Simhag A, El Rouby NMM, Azizi G. T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders. International Journal of Dermatology. 2015;54(8):880-888.
BibTex	@article{ author = {Mirshafiey A and Simhag A and El Rouby NMM and Azizi G}, title = {T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders}, journal = {International Journal of Dermatology}, volume = {54}, number = {8}, pages = {880-888}, year = {2015} }
RIS	TY - JOUR AU - Mirshafiey A AU - Simhag A AU - El Rouby NMM AU - Azizi G TI - T-Helper 22 Cells As a New Player in Chronic Inflammatory Skin Disorders JO - International Journal of Dermatology VL - 54 IS - 8 SP - 880 EP - 888 PY - 2015 ER -

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