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The Newly Identified T Helper 22 Cells Lodge in Leukemia



Azizi G1, 2 ; Pouyani MR3 ; Navabi SS3 ; Yazdani R2, 4 ; Kiaee F2 ; Mirshafiey A3
Authors
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Authors Affiliations
  1. 1. Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2015

Abstract

Leukemia is a hematological tumor in which the malignant myeloid or lymphoid subsets play a pivotal role. Newly identified T helper cell 22 (Th22) is a subset of CD4+ T cells with distinguished gene expression, function and specific properties apart from other known CD4+ T cell subsets.Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF-α). The levels of Th22 and cytokine IL-22 are increased and positively related to inflammatory and autoimmune disorders. Recently, several studies have reported the changes in frequency and function of Th22 in acute leukemic disorders as AML and ALL. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of leukemic disease. © 2015, Tehran University of Medical Sciences (TUMS). All rights reserved.
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