Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction

Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction Publisher Pubmed

Montazeri L¹ ; Kowsariesfahan R¹ ; Pahlavan S² ; Sobat M³ ; Rabbani S⁴ ; Ansari H² ; Varzideh F² ; Barekat M² ; Rajabi S¹ ; Navaee F⁵ ; Bonakdar S⁶ ; Renaud P⁵ ; Braun T⁷ ; Baharvand H^{2, 8}

Show Affiliations

1. Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
2. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
3. Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
4. Tehran Heart Center, Medical Sciences University of Tehran, Tehran, Iran
5. Microsystems Laboratory, Ecole Polytechnique Federale de Lausanne, EPFL-STIIMT- LMIS4, Station 17, Lausanne, 1015, Switzerland
6. National Cell Bank, Pasteur Institute of Iran, Tehran, Iran
7. Max-Planck Institute for Heart and Lung Research, Department of Cardiac Development and Remodeling, Bad Nauheim, Germany
8. Department of Developmental Biology, University of Science and Culture, Tehran, Iran

Source: Materials Science and Engineering C Published:2021

Abstract

To some extent, cell therapy for myocardial infarction (MI) has supported the idea of cardiac repair; however, further optimizations are inevitable. Combined approaches that comprise suitable cell sources and supporting molecules considerably improved its effect. Here, we devised a strategy of simultaneous transplantation of human cardiac progenitor cells (CPCs) and an optimized oxygen generating microparticles (MPs) embedded in fibrin hydrogel, which was injected into a left anterior descending artery (LAD) ligating-based rat model of acute myocardial infarction (AMI). Functional parameters of the heart, particularly left ventricular systolic function, markedly improved and reached pre-AMI levels. This functional restoration was well correlated with substantially lower fibrotic tissue formation and greater vascular density in the infarct area. Our novel approach promoted CPCs retention and differentiation into cardiovascular lineages. We propose this novel co-transplantation strategy for more efficient cell therapy of AMI which may function by providing an oxygen-rich microenvironment, and thus regulate cell survival and differentiation. © 2020 Elsevier B.V.

Style	Citing Format
MLA	Montazeri L, et al.. "Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction." Materials Science and Engineering C, vol. 121, no. , 2021, pp. -.
APA	Montazeri L, Kowsariesfahan R, Pahlavan S, Sobat M, Rabbani S, Ansari H, Varzideh F, Barekat M, Rajabi S, Navaee F, Bonakdar S, Renaud P, Braun T, Baharvand H (2021). Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction. Materials Science and Engineering C, 121(), -.
Chicago	Montazeri L, Kowsariesfahan R, Pahlavan S, Sobat M, Rabbani S, Ansari H, Varzideh F, et al.. "Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction." Materials Science and Engineering C 121, no. (2021): -.
Harvard	Montazeri L et al. (2021) 'Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction', Materials Science and Engineering C, 121(), pp. -.
Vancouver	Montazeri L, Kowsariesfahan R, Pahlavan S, Sobat M, Rabbani S, Ansari H, et al.. Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction. Materials Science and Engineering C. 2021;121():-.
BibTex	@article{ author = {Montazeri L and Kowsariesfahan R and Pahlavan S and Sobat M and Rabbani S and Ansari H and Varzideh F and Barekat M and Rajabi S and Navaee F and Bonakdar S and Renaud P and Braun T and Baharvand H}, title = {Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction}, journal = {Materials Science and Engineering C}, volume = {121}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Montazeri L AU - Kowsariesfahan R AU - Pahlavan S AU - Sobat M AU - Rabbani S AU - Ansari H AU - Varzideh F AU - Barekat M AU - Rajabi S AU - Navaee F AU - Bonakdar S AU - Renaud P AU - Braun T AU - Baharvand H TI - Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction JO - Materials Science and Engineering C VL - 121 IS - SP - EP - PY - 2021 ER -

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