Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Peptide Acylation in Aliphatic Polyesters: A Review of Mechanisms and Inhibition Strategies Publisher Pubmed



Sheikhi M1 ; Nemayandeh N1 ; Shirangi M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Science Tehran, Tehran, Iran

Source: Pharmaceutical Research Published:2024


Abstract

Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in developing a polyester-based delivery system for peptides is the acylation reaction between peptides and polymers. Peptide acylation is an important factor that affects formulation stability and can occur during storage, in vitro release, and after drug administration. This review focuses on the mechanisms and parameters that influence the rate of peptide acylation within polyesters. Furthermore, it discusses reported strategies to minimize the acylation reaction. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Related Docs
View other Related Docs
1. Inhibition of Octreotide Acylation Inside Plga Microspheres by Derivatization of the Amines of the Peptide With a Self-Immolative Protecting Group, Bioconjugate Chemistry (2016)
2. Acylation of Arginine in Goserelin-Loaded Plga Microspheres, European Journal of Pharmaceutics and Biopharmaceutics (2016)
3. Design of Experiments Approach for the Development of a Validated Method to Determine the Exenatide Content in Poly(Lactide-Co-Glycolide) Microspheres, European Journal of Pharmaceutics and Biopharmaceutics (2023)
4. Identification and Assessment of Octreotide Acylation in Polyester Microspheres by Lc-Ms/Ms, Pharmaceutical Research (2015)
5. Clinically Established Biodegradable Long Acting Injectables: An Industry Perspective, Advanced Drug Delivery Reviews (2020)
6. Poly(Lactic Acid)/Poly(Lactic-Co-Glycolic Acid) Particulate Carriers for Pulmonary Drug Delivery, Journal of Pharmaceutical Investigation (2019)
7. Development of Octreotide-Loaded Chitosan and Heparin Nanoparticles: Evaluation of Surface Modification Effect on Physicochemical Properties and Macrophage Uptake, Journal of Pharmaceutical Sciences (2019)
8. Engineered Plga Microspheres for Extended-Release of Naltrexone: In Vitro, In Vivo, and Ivivr, Pharmaceutical Development and Technology (2023)
Experts (# of related papers)
View all Related Experts
Mohsen Amini (3)
Rassoul Dinarvand (3)
Other Related Docs
9. Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals, Pharmaceutics (2018)
10. Nano-Immunotherapy: Overcoming Delivery Challenge of Immune Checkpoint Therapy, Journal of Nanobiotechnology (2023)
11. Preparation of Paclitaxel and Etoposide Co-Loaded Mpeg-Plga Nanoparticles: An Investigation With Artificial Neural Network, Journal of Pharmaceutical Innovation (2021)
12. Encapsulation of Crocetin Into Poly (Lactic-Co-Glycolic Acid) Nanoparticles Overcomes Drug Resistance in Human Ovarian Cisplatin-Resistant Carcinoma Cell Line (A2780-Rcis), Molecular Biology Reports (2019)
13. Albuminated Plga Nanoparticles Containing Bevacizumab Intended for Ocular Neovascularization Treatment, Journal of Biomedical Materials Research - Part A (2015)
14. Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases, Journal of Molecular Neuroscience (2022)
15. Forced Degradation Products of Liraglutide: A Comparative Study of Similarity Between Originator and Analogue Version by Liquid Chromatography–Mass Spectrometry, International Journal of Peptide Research and Therapeutics (2024)
16. Syntehsis and Evaluation of Gd3+ -Trp-Plga As Novel Nanosized Mr Tumor Imaging Candidate, Nanomedicine Journal (2021)
17. In-Vitro and In-Vivo Comparison of Rsag1-Loaded Plga Prepared by Encapsulation and Adsorption Methods As an Efficient Vaccine Against Toxoplasma Gondii”, Journal of Drug Delivery Science and Technology (2020)
18. The Recent Advancement in the Plga-Based Thermo-Sensitive Hydrogel for Smart Drug Delivery, International Journal of Pharmaceutics (2023)
19. Targeting Neuroinflammation by Intranasal Delivery of Nanoparticles in Neurological Diseases: A Comprehensive Review, Naunyn-Schmiedeberg's Archives of Pharmacology (2022)
20. Atopic Dermatitis Treatment: A Comprehensive Review of Conventional and Novel Bioengineered Approaches, International Journal of Biological Macromolecules (2024)
21. Intravenous Injection of Myelin Oligodendrocyte Glycoprotein-Coated Plga Microparticles Have Tolerogenic Effects in Experimental Autoimmune Encephalomyelitis, Iranian Journal of Allergy# Asthma and Immunology (2017)
22. Preparation, Characterization and in Vitro Evaluation of Insulin-Phbv Nanoparticles/Alginate Hydrogel Composite System for Prolonged Delivery of Insulin, Journal of Pharmaceutical Sciences (2024)
23. Recent Advances on Biocompatible and Biodegradable Nanoparticles As Gene Carriers, Expert Opinion on Biological Therapy (2016)
24. Preparation of Surface-Modified Plga Nanoparticles Containing Carbon Quantum Dots: Insights From C6 Cell Line Assays, Nanomedicine (2025)
25. Emerging Role of Nanotechnology in Treatment of Non-Alcoholic Fatty Liver Disease (Nafld), EXCLI Journal (2023)
26. Metal-Based Nanostructures/Plga Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications, ACS Applied Materials and Interfaces (2020)
27. Pharmaceutical Implants: Classification, Limitations and Therapeutic Applications, Pharmaceutical Development and Technology (2020)
28. Ignoring the Modeling Approaches: Towards the Shadowy Paths in Nanomedicine, Journal of Controlled Release (2018)
29. Nano Conjugated Plga-Chlorambucil: Synthesis in Vitro Anti Non-Hodgkin's Lymphoma Cellular Assay, Letters in Drug Design and Discovery (2017)
30. A New Insight Into the Mechanism of Loading of Granisetron, Naltrexone and Risperidone in Poly(Ortho Ester) and Poly (Lactic-Co-Glycolic Acid) As the Controlled Release Drug Delivery Systems Using a Computational Molecular Approach, Journal of Drug Delivery Science and Technology (2024)