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A Modified Sensitive Carbon Paste Electrode for 5-Fluorouracil Based Using a Composite of Praseodymium Erbium Tungstate Publisher



Rahiminasrabadi M1, 2 ; Ahmadi F3, 4 ; Beigizadeh H5 ; Karimi MS5 ; Sobhaninasab A6, 7 ; Joseph Y8 ; Ehrlich H8 ; Ganjali MR5, 9
Authors
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Authors Affiliations
  1. 1. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran
  6. 6. Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Core Research Lab, Kashan University of Medical Sciences, Kashan, Iran
  8. 8. IESEM, TU Bergakademie, Germany
  9. 9. Biosensor Research Centre, Endocrinology & Metabolism Molecular and Cellular Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Microchemical Journal Published:2020


Abstract

This paper describes the modification of a modified carbon paste electrode (CPE) using nanoparticles of praseodymium erbium tungstate (Pr:Er). The modified electrode was used for the sensitive voltammetric detection of an anticancer drug (5-fluorouracil (5-FU)) using. The modified-CPE was evaluated using cyclic voltammetry (CV), square wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS) and the resulting data showed the irreversible 5-fluorouracil oxidation peak around 1.0 V vs. Ag/AgCl. Some key parameters such as pH, the amount of the modifier, potential amplitude, step potential and frequency were studied and optimized. The square wave voltammetry (SWV) analytical calibration curve was linear in the range of 0.01–50 μM, with a detection limit of 0.98 nM analyses. The electron transfer coefficient (α) was also determined to be 0.76. The analyte concentration was also determined in pharmaceutical formulations and recovery percentages were found to be in the range of 96–102%. The sensor had good reproducibility and repeatability with acceptable RSD values of 3.6%, and 1.02% and a rather long-term stability of around one month. The as-synthesized nanoparticles were also characterized using FESEM, TEM, FTIR and XRD techniques. © 2020 Elsevier B.V.
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