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Exosomal Micrornas As Potential Circulating Biomarkers in Gastrointestinal Tract Cancers: A Systematic Review Protocol Publisher Pubmed



Gheytanchi E1 ; Madjd Z2 ; Janani L3 ; Rasti A1 ; Ghods R4 ; Atyabi F5 ; Lari MHA6 ; Babashah S7
Authors
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Authors Affiliations
  1. 1. Iran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran
  2. 2. Iran University of Medical Sciences, Oncopathology Research Center, Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Tehran, Iran
  3. 3. Iran University of Medical Sciences, Department of Biostatistics, School of Public Health, Tehran, Iran
  4. 4. Iran University of Medical Sciences, Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Oncopathology Research Center, Tehran, Iran
  5. 5. Tehran University of Medical Sciences, Department of Pharmaceutics, Nanotechnology Research Center, Faculty of Pharmacy, Tehran, Iran
  6. 6. University of British Columbia (UBC), Department of Cellular and Physiological Sciences, Faculty of Medicine, Vancouver, BC, Canada
  7. 7. Tarbiat Modares University, Department of Molecular Genetics, Faculty of Biological Sciences, Tehran, Iran

Source: Systematic Reviews Published:2017


Abstract

Background: Metastasis is the most frequent type of recurrence in gastrointestinal (GI) cancers, and there is an emerging potential for new diagnostic and therapeutic approaches, especially in the cases of metastatic GI carcinomas. The expression profiles of circulating exosomal microRNAs are of particular interest as novel non-invasive diagnostic and prognostic biomarkers for improved detection of GI cancers in body fluids, especially in the serum of patients with recurrent cancers. The aim of this study is to systematically review primary studies and identify the miRNA profiles of serum exosomes of GI cancers. Methods and design: This systematic review will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidance. Relevant studies will be identified through a comprehensive search of the following main electronic databases: PubMed, Web of Science, Embase, Scopus, and Google Scholar, with no language restrictions (up to July 2017). Full copies of articles will be identified by a defined search strategy and will be considered for inclusion against pre-defined criteria. The quality assessment of the included studies will be performed by the Newcastle-Ottawa Scale (NOS). Data will be analyzed using Stata software V.12. Publication bias will be assessed by funnel plots, Beggs' and Eggers' tests. The levels of evidence for primary outcomes will be evaluated using the GRADE criteria. Discussion: The analysis of circulating exosomal miRNA profiles provides attractive screening and non-invasive diagnostic tools for the majority of solid tumors including GI cancers. There is limited information regarding the relationship between serum exosomal miRNA profiles and the pathological condition of patients with different GI cancers. Since there is no specific biomarker for GI cancers, we aim to suggest a number of circulating exosomal miRNA candidates as potential multifaceted GI cancer biomarkers for clinical utility. Systematic review registration: PROSPERO CRD42017057129 © 2017 The Author(s).
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