Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart

Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart Publisher Pubmed

Wei K^{1, 2} ; Serpooshan V³ ; Hurtado C^{1, 2} ; Diezcunado M^{1, 2, 3} ; Zhao M³ ; Maruyama S⁴ ; Zhu W^{1, 2} ; Fajardo G³ ; Noseda M⁵ ; Nakamura K⁴ ; Tian X⁶ ; Liu Q⁶ ; Wang A³ ; Matsuura Y³ Show All Authors

Wei K^{1, 2}
Serpooshan V³
Hurtado C^{1, 2}
Diezcunado M^{1, 2, 3}
Zhao M³
Maruyama S⁴
Zhu W^{1, 2}
Fajardo G³
Noseda M⁵
Nakamura K⁴
Tian X⁶
Liu Q⁶
Wang A³
Matsuura Y³
Bushway P^{1, 2}
Cai W^{1, 2}
Savchenko A^{1, 2}
Mahmoudi M^{3, 7}
Schneider MD⁵
Van Den Hoff MJB⁸
Butte MJ³
Yang PC³
Walsh K⁴
Zhou B^{6, 9}
Bernstein D³
Mercola M^{1, 2}
Ruizlozano P³

Show Affiliations

1. Department of Bioengineering, University of California, San Diego, 92037, CA, United States
2. Sanford-Burnham-Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, San Diego, 92037, CA, United States
3. Stanford Cardiovascular Institute, Department of Pediatrics, Stanford University, 300 Pasteur Drive, Stanford, 94305, CA, United States
4. Whitaker Cardiovascular Institute, Boston University, School of Medicine, Boston, 02118, MA, United States
5. Imperial College London, Faculty of Medicine, Imperial Centre for Translational and Experimental Medicine, Du Cane Road, London, W120NN, United Kingdom
6. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Shanghai, 200031, China
7. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
8. Academic Medical Center, Dept Anatomy, Embryology and Physiology, Meibergdreef 15, Amsterdam, 1105, Netherlands
9. CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

Source: Nature Published:2015

Abstract

The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. Myocardial Fstl1 does not promote regeneration, either basally or upon transgenic overexpression. Application of the human Fstl1 protein (FSTL1) via an epicardial patch stimulates cell cycle entry and division of pre-existing cardiomyocytes, improving cardiac function and survival in mouse and swine models of myocardial infarction. The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans. © 2015 Macmillan Publishers Limited.

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Alimohammad Alizadeh (1)

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Style	Citing Format
MLA	Wei K, et al.. "Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart." Nature, vol. 525, no. 7570, 2015, pp. 479-485.
APA	Wei K, Serpooshan V, Hurtado C, Diezcunado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, ... Ruizlozano P (2015). Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart. Nature, 525(7570), 479-485.
Chicago	Wei K, Serpooshan V, Hurtado C, Diezcunado M, Zhao M, Maruyama S, Zhu W, et al.. "Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart." Nature 525, no. 7570 (2015): 479-485.
Harvard	Wei K et al. (2015) 'Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart', Nature, 525(7570), pp. 479-485.
Vancouver	Wei K, Serpooshan V, Hurtado C, Diezcunado M, Zhao M, Maruyama S, et al.. Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart. Nature. 2015;525(7570):479-485.
BibTex	@article{ author = {Wei K and Serpooshan V and Hurtado C and Diezcunado M and Zhao M and Maruyama S and Zhu W and Fajardo G and Noseda M and Nakamura K and Tian X and Liu Q and Wang A and Matsuura Y and Bushway P and Cai W and Savchenko A and Mahmoudi M and Schneider MD and Van Den Hoff MJB and Butte MJ and Yang PC and Walsh K and Zhou B and Bernstein D and Mercola M and Ruizlozano P}, title = {Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart}, journal = {Nature}, volume = {525}, number = {7570}, pages = {479-485}, year = {2015} }
RIS	TY - JOUR AU - Wei K AU - Serpooshan V AU - Hurtado C AU - Diezcunado M AU - Zhao M AU - Maruyama S AU - Zhu W AU - Fajardo G AU - Noseda M AU - Nakamura K AU - Tian X AU - Liu Q AU - Wang A AU - Matsuura Y AU - Bushway P AU - Cai W AU - Savchenko A AU - Mahmoudi M AU - Schneider MD AU - Van Den Hoff MJB AU - Butte MJ AU - Yang PC AU - Walsh K AU - Zhou B AU - Bernstein D AU - Mercola M AU - Ruizlozano P TI - Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart JO - Nature VL - 525 IS - 7570 SP - 479 EP - 485 PY - 2015 ER -

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