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Use of Single-Chain Antibody Derivatives for Targeted Drug Delivery Publisher



Safdari Y1, 7 ; Ahmadzadeh V2, 3 ; Khalili M4 ; Jaliani HZ5 ; Zarei V6 ; Erfanimoghadam V1, 7
Authors
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Authors Affiliations
  1. 1. Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, Iran
  7. 7. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Source: Molecular Medicine Published:2016


Abstract

Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery. In this review, we discuss how scFvs help improve the specificity and efficiency of drugs. Small interfering RNA (siRNA) delivery using scFv-drug fusion peptides, siRNA delivery using scFv-conjugated nanoparticles, targeted delivery using scFv-viral peptide-fusion proteins, use of scFv in fusion with cell-penetrating peptides for effective targeted drug delivery, scFv-mediated targeted delivery of inorganic nanoparticles, scFv-mediated increase of tumor killing activity of granulocytes, use of scFv for tumor imaging, site-directed conjugation of scFv molecules to drug carrier systems, use of scFv to relieve pain and use of scFv for increasing drug loading efficiency are among the topics that are discussed here. © 2016, University of Michigan. All rights reserved.
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