The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts

The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts Publisher

Doraghi F¹ ; Serajian A² ; Karimian S³ ; Larijani B¹ ; Mahdavi M¹

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1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, Iran
3. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Chemical Papers Published:2024

Abstract

Pyridinium salts have been used as starting materials and intermediates in 1,3-dipolar cycloaddition with dipolarophiles. Among them, N-phenacylpyridinium salts can easily react with dipolarophiles due to having a good electron-attracting COPh group. This group can stabilize pyridinium ylide generated in situ from N-phenacylpyridinium salts. The synthesis of a wide variety of biologically active N-, O-, and S-heterocycles, as well as carbocycles, can be achieved from N-phenacylpyridinium salt precursors. This review highlights important cyclization and functionalization reactions, involving N-phenacylpyridinium salts. Graphical abstract: N-phenacylpyridinium salts, an important subclass of pyridinium salts, serve as an intermediate, as well as a starting material in the synthesis of a diverse range of N-, O-, and S-heterocycles, as well as carbocycles. The construction of important biologically active molecules, such as indolizine, pyridine, quinoline, pyrrole, azepine, dihydrofuran, and chromene, can be achieved from N-phenacylpyridinium salt precursors. This review highlights cyclization and functionalization reactions, involving N-phenacylpyridinium salts. (Figure presented.) © The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2024.

Style	Citing Format
MLA	Doraghi F, et al.. "The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts." Chemical Papers, vol. 78, no. 12, 2024, pp. 6821-6841.
APA	Doraghi F, Serajian A, Karimian S, Larijani B, Mahdavi M (2024). The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts. Chemical Papers, 78(12), 6821-6841.
Chicago	Doraghi F, Serajian A, Karimian S, Larijani B, Mahdavi M. "The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts." Chemical Papers 78, no. 12 (2024): 6821-6841.
Harvard	Doraghi F et al. (2024) 'The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts', Chemical Papers, 78(12), pp. 6821-6841.
Vancouver	Doraghi F, Serajian A, Karimian S, Larijani B, Mahdavi M. The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts. Chemical Papers. 2024;78(12):6821-6841.
BibTex	@article{ author = {Doraghi F and Serajian A and Karimian S and Larijani B and Mahdavi M}, title = {The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts}, journal = {Chemical Papers}, volume = {78}, number = {12}, pages = {6821-6841}, year = {2024} }
RIS	TY - JOUR AU - Doraghi F AU - Serajian A AU - Karimian S AU - Larijani B AU - Mahdavi M TI - The Cyclization and Functionalization Reactions Involving N-Phenacylpyridinium Salts JO - Chemical Papers VL - 78 IS - 12 SP - 6821 EP - 6841 PY - 2024 ER -

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