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Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin Publisher Pubmed



Vaseghi S1, 2 ; Arjmandirad S3 ; Nasehi M1 ; Zarrindast MR2, 4
Authors
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Authors Affiliations
  1. 1. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  3. 3. Institute for Cognitive & Brain Sciences, Shahid Beheshti University, Tehran, Iran
  4. 4. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Behavioural Brain Research Published:2021


Abstract

Cannabis sativa (Marijuana) has a long history as a medicinal plant and Δ9-tetrahydrocannabinol (Δ9-THC) is the most active component in this plant. Cannabinoids are interesting compounds with various modulatory effects on physiological processes and cognitive functions. The use of cannabinoids is a double-edged sword, because they induce both adverse and therapeutic properties. One of the most important roles of cannabinoids is modulating sleep-wake cycle. Sleep, its cycle, and its mechanism are highly unknown. Also, the effects of cannabinoids on sleep-wake cycle are so inconsistent. Thus, understanding the role of cannabinoids in modulating sleep-wake cycle is a critical scientific goal. Cannabinoids interact with many neurotransmitter systems. In this review article, we chose serotonin due to its important role in regulating sleep-wake cycle. We found that the interaction between cannabinoids and serotonergic signaling especially in the dorsal raphe is extensive, unknown, and controversial. © 2021 Elsevier B.V.
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