Tehran University of Medical Sciences

Science Communicator Platform

Share By
Existing Antiviral Options Against Sars-Cov-2 Replication in Covid-19 Patients Publisher Pubmed

Summary: How can we quickly combat COVID-19? Review identifies promising broad-spectrum antiviral repurposing options targeting virus functions, a vital strategy for immediate response! #COVID19 #AntiviralDrugs

Ghanbari R1 ; Teimoori A2 ; Sadeghi A1 ; Mohamadkhani A1 ; Rezasoltani S3 ; Asadi E4 ; Jouyban A5 ; Sumner SCJ6
Authors

Source: Future Microbiology Published:2020


Abstract

COVID-19 caused by SARS-CoV-2, is an international concern. This infection requires urgent efforts to develop new antiviral compounds. To date, no specific drug in controlling this disease has been identified. Developing the new treatment is usually time consuming, therefore using the repurposing broad-spectrum antiviral drugs could be an effective strategy to respond immediately. In this review, a number of broad-spectrum antivirals with potential efficacy to inhibit the virus replication via targeting the virus spike protein (S protein), RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro) that are critical in the pathogenesis and life cycle of coronavirus, have been evaluated as possible treatment options against SARS-CoV-2 in COVID-19 patients. © 2021 Future Medicine Ltd
Related Docs
View other Related Docs
1. Can Anti-Parasitic Drugs Help Control Covid-19?, Future Virology (2022)
2. Lifesaving Combined Treatment in a Rapidly Progressive Covid-19 Pneumonia Case With Extensive Lung Involvement, Biomedical and Biotechnology Research Journal (2020)
3. Potential Therapeutic Options for Covid-19: An Update on Current Evidence, European Journal of Medical Research (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (7)
Azar Hadadi (1)
Existing Antiviral Options Against Sars-Cov-2 Replication in Covid-19 Patients
Other Related Docs
4. Therapeutic Potentials and Candidates for Covid-19, Iranian Journal of Science (2023)
5. Covid-19: A Review on Treatment Strategies and Candidate Vaccines, Scientific Journal of Kurdistan University of Medical Sciences (2021)
6. Recent Advances in Passive Immunotherapies for Covid-19: The Evidence-Based Approaches and Clinical Trials, International Immunopharmacology (2022)
7. Antiviral Optical Techniques As a Possible Novel Approach to Covid-19 Treatment*, (2024)
8. Therapeutic Strategies for Covid-19 Patients: An Update, Infectious Disorders - Drug Targets (2022)
9. The Emergence of Novel Coronavirus Disease, Global Treatment Update and Its Containment Strategies in Overpopulated Countries: A Review, Coronaviruses (2021)
10. Potential Role of Interferons in Treating Covid-19 Patients, International Immunopharmacology (2021)
11. Antiviral Optical Techniques As a Possible Novel Approach to Covid-19 Treatment, Journal of Innovative Optical Health Sciences (2021)
12. A Review on Currently Available Potential Therapeutic Options for Covid-19, International Journal of General Medicine (2020)
13. Phytopharmaceuticals Mediated Furin and Tmprss2 Receptor Blocking: Can It Be a Potential Therapeutic Option for Covid-19?, Phytomedicine (2021)
14. Overview of the Current Promising Approaches for the Development of an Effective Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Vaccine, International Immunopharmacology (2020)
15. Covid-19: Transmission, Prevention, and Potential Therapeutic Opportunities, Clinica Chimica Acta (2020)
16. Computational Drug Discovery and Repurposing for the Treatment of Covid-19: A Systematic Review, Bioorganic Chemistry (2021)
17. Prophylaxis With Chloroquine and Hydroxychloroquine in Covid-19, Journal of Iranian Medical Council (2020)
18. Oral Antiviral Treatments for Covid-19: Opportunities and Challenges, Pharmacological Reports (2022)
19. Sars-Cov-2: From the Pathogenesis to Potential Anti-Viral Treatments, Biomedicine and Pharmacotherapy (2021)
20. Virtual Screening Based on the Structure of More Than 105 Compounds Against Four Key Proteins of Sars-Cov-2: Mpro, Srbd, Rdrp, and Plpro, Informatics in Medicine Unlocked (2022)