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A Review on Α-Glucosidase Inhibitory Activity of First Row Transition Metal Complexes: A Futuristic Strategy for Treatment of Type 2 Diabetes Publisher



Sohrabi M1 ; Binaeizadeh MR2 ; Iraji A3, 4, 5 ; Larijani B1 ; Saeedi M6, 7 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Endocrinology and Metabolism Clinical Sciences Institute, Tehran, Iran
  2. 2. School of Chemistry, University of Tehran, College of Science, Tehran, Iran
  3. 3. Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Liosa Pharmed Parseh Company, Shiraz, Iran
  6. 6. Medicinal Plants Research Center, Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran
  7. 7. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: RSC Advances Published:2022


Abstract

Type 2 diabetes mellitus (T2DM) is characterized by high blood glucose levels and has emerged as a controversial public health issue worldwide. The increasing number of patients with T2DM on one hand, and serious long-term complications of the disease such as obesity, neuropathy, and vascular disorders on the other hand, have induced a huge economic impact on society globally. In this regard, inhibition of α-glucosidase, the enzyme responsible for the hydrolysis of carbohydrates in the body has been the main therapeutic approach to the treatment of T2DM. As α-glucosidase inhibitors (α-GIs) have occupied a special position in the current research and prescription drugs are generally α-GIs, researchers have been encouraged to design and synthesize novel and efficient inhibitors. Previously, the presence of a sugar moiety seemed to be crucial for designing α-GIs since they can attach to the carbohydrate binding site of the enzyme mimicking the structure of disaccharides or oligosaccharides. However, inhibitors lacking glycosyl structures have also shown potent inhibitory activity and development of non-sugar based inhibitors is accelerating. In this respect, in vitro anti-α-glucosidase activity of metal complexes has attracted lots of attention and this paper has reviewed the inhibitory activity of first-row transition metal complexes toward α-glucosidase and discussed their probable mechanisms of action. © 2022 The Royal Society of Chemistry.