Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Application of Direct Viral Cytopathic Hypothesis to Design Drug Trials in the Battle Against Covid-19 Publisher Pubmed



Ashraf MA1 ; Sherafat A2 ; Pourdast A3, 4 ; Nazemi P4 ; Mohraz M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. School of Medicine, University of Central Lancashire, Preston, United Kingdom
  3. 3. Iranian Research Center for HIV/AIDS (IRCHA), District 6, Imam Khomeini Hospital, Keshavarz Blvd, Nosrat St, Tehran, Tehran Province, Iran
  4. 4. Tehran University of Medical Sciences, Tehran, Iran

Source: DARU# Journal of Pharmaceutical Sciences Published:2020


Abstract

COVID-19 has caused many deaths worldwide. Systemic complications alongside coagulopathy, and ARDS account for the majority of COVID-19 mortalities. The pathogenesis of the disease can be explained by two theories of direct viral cytopathy and systemic inflammatory cascade of events. ACE-2 is shown to be the cellular host receptor for SARS-CoV-2. It might be the key to explain the pathogenesis of systemic complications with a focus on the direct viral cytopathic hypothesis. Different medications tend to show up in many in vitro drug screens. However, more trials are needed to translate their application into in vivo efficacy. © 2020, Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. Classification of the Present Pharmaceutical Agents Based on the Possible Effective Mechanism on the Covid-19 Infection, DARU# Journal of Pharmaceutical Sciences (2020)
2. Covid-19 and Multiorgan Failure: A Narrative Review on Potential Mechanisms, Journal of Molecular Histology (2020)
3. Sars-Cov-2: Current Trends in Emerging Variants, Pathogenesis, Immune Responses, Potential Therapeutic, and Vaccine Development Strategies, International Immunopharmacology (2021)
4. Cardiac Injury Is Associated With Severe Outcome and Death in Patients With Coronavirus Disease 2019 (Covid-19) Infection: A Systematic Review and Meta-Analysis of Observational Studies, European Heart Journal: Acute Cardiovascular Care (2020)
5. Molecular Signaling Pathways, Pathophysiological Features in Various Organs, and Treatment Strategies in Sars-Cov2 Infection, Acta Histochemica (2022)
6. Pathophysiology of Covid-19 Infection: What Is the Novel Coronavirus (Sars-Cov-2) Doing to Body? a Comprehensive Systematic Review, Reviews and Research in Medical Microbiology (2021)
7. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
8. A Case of Multiple Large Left Ventricular Clots in a Patient With Covid-19, International Cardiovascular Research Journal (2021)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (13)
Niloofar Ayoobi Yazdi (2)
Other Related Docs
9. Covid-19: Review of a 21St Century Pandemic From Etiology to Neuro-Psychiatric Implications, Journal of Alzheimer's Disease (2020)
10. Targeted Therapy Strategies Against Sars-Cov-2 Cell Entry Mechanisms: A Systematic Review of in Vitro and in Vivo Studies, Journal of Cellular Physiology (2021)
11. Risk Factors for Mortality in Patients With Coronavirus Disease 2019 (Covid-19) Infection: A Systematic Review and Meta-Analysis of Observational Studies, Aging Male (2021)
12. Severe Acute Respiratory Syndrome-Coronavirus-2 Spike (S) Protein Based Vaccine Candidates: State of the Art and Future Prospects, Reviews in Medical Virology (2021)
13. Towards Treatment Planning of Covid-19: Rationale and Hypothesis for the Use of Multiple Immunosuppressive Agents: Anti-Antibodies, Immunoglobulins, and Corticosteroids, International Immunopharmacology (2020)
14. Coagulopathy and Thromboembolic Events a Pathogenic Mechanism of Covid-19 Associated With Mortality: An Updated Review, Journal of Clinical Laboratory Analysis (2023)
15. Sars-Cov-2: A Comprehensive Review From Pathogenicity of the Virus to Clinical Consequences, Journal of Medical Virology (2020)
16. The Immunologic Basis of Covid-19: A Clinical Approach, Journal of Cellular and Molecular Anesthesia (2020)
17. Renal, Cardiac, Neurological, Cutaneous and Coagulopathic Long-Term Manifestations of Covid-19 After Recovery; a Review, Epidemiology and Infection (2022)
18. Is Prior Use of Renin-Angiotensin System (Ras) Inhibitors Associated With More Favourable Outcome in Covid-19 Hospitalized Patients?, Frontiers in Emergency Medicine (2022)
19. Immune-Based Therapy for Covid-19, Advances in Experimental Medicine and Biology (2021)
20. The Prophylaxis and Treatment Potential of Supplements for Covid-19, European Journal of Pharmacology (2020)
21. Biochemical Parameters and Pathogenesis of Sars-Cov-2 Infection in Vital Organs: Covid-19 Outbreak in Iran, New Microbes and New Infections (2020)
22. Pharmacological Treatments of Covid-19, Pharmacological Reports (2020)
23. Advances in Immunotherapy for Covid-19: A Comprehensive Review, International Immunopharmacology (2021)
24. The Association Between Cardiac Injury and Outcomes in Hospitalized Patients With Covid-19, Internal and Emergency Medicine (2020)
25. Cardiopulmonary Predictors of Mortality in Patients With Covid-19: What Are the Findings?; [Predicteurs Cardio-Pulmonaire De La Mortalite Chez Les Patients Ayant La Covid-19 : Quel Eclairage?], Archives of Cardiovascular Diseases (2022)
26. The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection, International Immunopharmacology (2021)
27. Fatty Liver in Covid-19: A Risk Factor or a Common Receptor?, Archives of Iranian Medicine (2021)
28. State-Of-The-Art of Nanodiagnostics and Nanotherapeutics Against Sars-Cov-2, ACS Applied Materials and Interfaces (2021)
29. Covid-19 Infection and Stroke Risk, Reviews in the Neurosciences (2021)
30. Cardiac Complications in Covid-19: A Systematic Review and Meta-Analysis, Archives of Iranian Medicine (2021)
31. What Is Important in Patients With Covid-19 Associated With Myocardial Infarction?, Journal of Tehran University Heart Center (2020)
32. How Prevalent Is Cancer in Confirmed Cases With Coronaviruses and Severe Acute Respiratory Syndromes?, Advances in Experimental Medicine and Biology (2021)
33. Acute Cardiac Injury in Covid-19: A Systematic Review and Meta-Analysis, Archives of Iranian Medicine (2020)
34. Design of Novel Disturbing Peptides Against Ace2 Sars-Cov-2 Spike-Binding Region by Computational Approaches, Frontiers in Pharmacology (2022)
35. Kidney Diseases and Covid-19 Infection: Causes and Effect, Supportive Therapeutics and Nutritional Perspectives, Heliyon (2021)
36. Soluble Ace2 As a Risk or Prognostic Factor in Covid-19 Patients: A Cross-Sectional Study, Medical Journal of the Islamic Republic of Iran (2022)
37. Immune Profiling of Sars-Cov-2; What We Know and What We Don’T Know, Iranian Journal of Allergy# Asthma and Immunology (2023)
38. Intracranial Aneurysm Rupture After Sars-Cov2 Infection: Case Report and Review of Literature, Pathogens (2022)
39. Positive Association Between Severity of Covid-19 Infection and Liver Damage: A Systematic Review and Meta-Analysis, Gastroenterology and Hepatology from Bed to Bench (2020)
40. Covid-19 Pandemic and Biological Therapy in Rheumatologic Disorders: How to Deal With?, Reumatismo (2020)
41. Cytokines and Covid-19: Friends or Foes?, Human Vaccines and Immunotherapeutics (2020)
42. Variable Clinical Manifestations of Covid-19: Viral and Human Genomes Talk, Iranian Journal of Allergy# Asthma and Immunology (2020)
43. Urinary Viral Shedding of Covid-19 and Its Clinical Associations: A Systematic Review and Meta-Analysis of Observational Studies, Urology Journal (2020)
44. Pathologic Features of Covid-19: A Concise Review, Pathology Research and Practice (2020)
45. Covid-19: Transmission, Prevention, and Potential Therapeutic Opportunities, Clinica Chimica Acta (2020)
46. What Is Important in Patients With Covid-19 Associated With Myocardial Infarction?, Journal of Tehran University Heart Center (2020)
47. What Dentists Need to Know About Covid-19, Oral Oncology (2020)
48. Evaluation of Mir-200C-3P and Mir-421-5P Levels During Immune Responses in the Admitted and Recovered Covid-19 Subjects, Infection# Genetics and Evolution (2022)
49. Biomarker Based Biosensors: An Opportunity for Diagnosis of Covid-19, Reviews in Medical Virology (2022)
50. Introduction on Coronavirus Disease (Covid-19) Pandemic: The Global Challenge, Advances in Experimental Medicine and Biology (2021)