Fluorescent Multi-Responsive Cross-Linked P(N-Isopropylacrylamide)-Based Nanocomposites for Cisplatin Delivery Publisher Pubmed



Shakoori Z¹ ; Ghanbari H¹ ; Omidi Y² ; Pashaiasl M^{3, 4} ; Akbarzadeh A^{5, 6} ; Jomeh Farsangi Z¹ ; Rezayat SM^{1, 7, 8, 9} ; Davaran S^{5, 10, 11} Show Affiliations
Source: Drug Development and Industrial Pharmacy Published:2017

Abstract

Magnetic, pH and temperature-sensitive, poly(N-isopropylacrylamide) (PNIPAM)-based nanocomposites with fluorescent properties were synthesized by free radical copolymerization-cross linking of NIPAM, N,N-dimethylaminoethyl methacrylate (DMAEMA) and 4-acrylamidofluorescein (AFA). The model anti-cancer drug, cisplatin (CDDP), was loaded into the resulted nanogel. For the production of CDDP-loaded nanocomposite, Fe3O4 magnetic nanoparticles (MNPs) and CDDP were loaded into the nanogel. Field-emission scanning electron microscopy (FE-SEM) indicated that the size of nanogel and CDDP-loaded nanocomposite were about 90 and 160 nm, respectively. The encapsulation efficiency of CCDP was found up to 65%. The loaded CCDP showed sustained thermal and pH-responsive drug release. A high level of drug release was observed under the conditions of low pH and high temperature. The lower critical solution temperature (LCST) of synthesized nanogel was about 40 °C. CDDP-loaded nanocomposite showed a volume phase transition from 282 to 128 nm at its LCST. Accordingly, in this study, the synthesized nanocomposite can be employed as a stimuli-responsive anti-cancer drug delivery system and the pH and temperature of solution have the potential to monitor the drug release. © 2017 Informa UK Limited, trading as Taylor & Francis Group.