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Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight From 2010 to 2020 Studies Publisher Pubmed



Abedinifar F1 ; Mahdavi M1 ; Asadi M1 ; Hamedifar H2 ; Ansari S2 ; Larijani B1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 14176, Iran
  2. 2. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Current Organic Synthesis Published:2021


Abstract

Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review. © 2021 Bentham Science Publishers.