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Curcumin: Footprints on Cardiac Tissue Engineering Publisher Pubmed



Kargozar S1 ; Baino F2 ; Hoseini SJ3 ; Verdi J4 ; Asadpour S5 ; Mozafari M6, 7
Authors
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Authors Affiliations
  1. 1. Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Applied Science and Technology Department, Institute of Materials Physics and Engineering, Torino, Italy
  3. 3. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Tissue Engineering & Applied Cell Sciences Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
  6. 6. Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Expert Opinion on Biological Therapy Published:2019


Abstract

Introduction: Curcumin-based products are extensively used as therapeutics in the treatment of cardiac disorders; however, there is no significant report on the curcumin potentials in cardiac tissue engineering applications. Due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties, curcumin has been demonstrated to be a promising candidate for tissue engineering (TE) applications. Areas covered: Various curcumin-containing tissue-engineered constructs have been developed for the management of soft tissue damages (such as wound injuries); hence, there are hopes for the use of this natural product in cardiac tissue engineering (CTE). However, some crucial issues should primarily be addressed before curcumin could be widely used in CTE. Expert opinion: The challenges regarding the use of curcumin in CTE include the optimum dosages of curcumin for promoting cardiac regeneration, the type of carrier used (e.g., polymeric matrices), the preferable release profile, as well as the short- and long-term toxicity in the human body. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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