Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Mrna Expression Levels of Il-17A and Il-10 Cytokines in Cervical Cancer Publisher



Akhavan S1 ; Safari A2 ; Azizmohammadi S3 ; Azizmohammadi S3 ; Aslami M4 ; Yahaghi E5 ; Seifoleslami M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, School of Medicine, Imam Khomeini Hospital Complex and Vali Asr Hospital, Oncology Ward, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Gynecology, Imam Reza Hospital, AJA University of Medical Sciences, Tehran, Iran
  3. 3. Department of Gynecology, Hajar Hospital, AJA University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biology, California State University Stanislaus, California, United States
  5. 5. Department of Molecular Biology, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Department of Gynecology, Khanevadeh Hospital, AJA University of Medical Sciences, Tehran, Iran

Source: Tumor Biology Published:2016


Abstract

In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients’ age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage. © 2016, International Society of Oncology and BioMarkers (ISOBM).
Related Docs
1. Pathogenic Role of Exosomes and Micrornas in Hpv-Mediated Inflammation and Cervical Cancer: A Review, International Journal of Cancer (2020)
2. Il-17 and Colorectal Cancer: From Carcinogenesis to Treatment, Cytokine (2019)
3. The Role of T Helper 17 and Regulatory T Cells in Tumor Microenvironment, Immunopharmacology and Immunotoxicology (2019)
4. Anti-Tumor Effects of Propranolol: Adjuvant Activity on a Transplanted Murine Breast Cancer Model, Biomedicine and Pharmacotherapy (2018)
5. Il-22 Produced by T Helper Cell 22 As a New Player in the Pathogenesis of Immune Thrombocytopenia, Endocrine# Metabolic and Immune Disorders - Drug Targets (2015)
6. The Paradox of Th17 Cell Functions in Tumor Immunity, Cellular Immunology (2017)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (1)
Nima Rezaei (1)