Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Using Metabolomics to Investigate Biomarkers of Drug Addiction Publisher Pubmed



Ghanbari R1, 2 ; Sumner S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  2. 2. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Trends in Molecular Medicine Published:2018


Abstract

Drug addiction has been associated with an increased risk for cancer, psychological complications, heart, liver, and lung disease, as well as infection. While genes have been identified that can mark individuals at risk for substance abuse, the initiation step of addiction is attributed to persistent metabolic disruptions occurring following the first instance of narcotic drug use. Advances in analytical technologies can enable the detection of thousands of signals in body fluids and excreta that can be used to define biochemical profiles of addiction. Today, these approaches hold promise for determining how exposure to drugs, in the absence or presence of other environmentally relevant factors, can impact human metabolism. We posit that these can lead to candidate biomarkers of drug dependence, treatment, withdrawal, or relapse. © 2017
Related Docs
View other Related Docs
1. Untargeted Metabolomics: Biochemical Perturbations in Golestan Cohort Study Opium Users Inform Intervention Strategies, Frontiers in Nutrition (2020)
2. Mortality From Respiratory Diseases Associated With Opium Use: A Population-Based Cohort Study, Thorax (2017)
3. Opium Use, Cigarette Smoking, and Alcohol Consumption in Relation to Pancreatic Cancer, Medicine (United States) (2016)
4. Individual and Combined Effects of Environmental Risk Factors for Esophageal Cancer Based on Results From the Golestan Cohort Study, Gastroenterology (2019)
5. Opium Use and Risk of Pancreatic Cancer: A Prospective Cohort Study, Cancer Epidemiology Biomarkers and Prevention (2018)
6. Opium Use and Subsequent Incidence of Cancer: Results From the Golestan Cohort Study, The Lancet Global Health (2020)
7. Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study, Cancer Epidemiology Biomarkers and Prevention (2020)
8. Fifty Years of Research and One Conclusion: Opium Causes Cancer, Archives of Iranian Medicine (2020)
Experts (# of related papers)
View all Related Experts
Reza Malekzadeh (43)
Hossein Poustchi (37)
Other Related Docs
9. Epidemiologic Study of Opium Use in Pars Cohort Study: A Study of 9000 Adults in a Rural Southern Area of Iran, Archives of Iranian Medicine (2017)
10. Causes of Premature Death and Their Associated Risk Factors in the Golestan Cohort Study, Iran, BMJ Open (2018)
11. The Iranian Study of Opium and Cancer (Iropican): Rationale, Design, and Initial Findings, Archives of Iranian Medicine (2021)
12. The Carcinogenicity of Opium Consumption: A Systematic Review and Meta-Analysis, European Journal of Epidemiology (2023)
13. Lead Poisoning Among Asymptomatic Individuals With a Long-Term History of Opiate Use in Golestan Cohort Study, International Journal of Drug Policy (2022)
14. Joint Effect of Diabetes and Opiate Use on All-Cause and Cause-Specific Mortality: The Golestan Cohort Study, International Journal of Epidemiology (2021)
15. The Marginal Causal Effect of Opium Consumption on the Upper Gastrointestinal Cancer Death Using Parametric G-Formula: An Analysis of 49,946 Cases in the Golestan Cohort Study, Iran, PLoS ONE (2021)
16. Cardiovascular Mortality in a Western Asian Country: Results From the Iran Cohort Consortium, BMJ Open (2018)
17. Cancer Incidence in the East Azerbaijan Province of Iran in 2015-2016: Results of a Population-Based Cancer Registry, BMC Public Health (2018)
18. Association Between Incident Type 2 Diabetes and Opium Use: Mediation by Body Mass and Adiposity, American Journal of Epidemiology (2023)
19. International Cancer Seminars: A Focus on Esophageal Squamous Cell Carcinoma, Annals of Oncology (2017)
20. Trends in the Incidence of Stomach Cancer in Golestan Province, a High-Risk Area in Northern Iran, 2004-2016, Archives of Iranian Medicine (2020)
21. The Application of Six Dietary Scores to a Middle Eastern Population: A Comparative Analysis of Mortality in a Prospective Study, European Journal of Epidemiology (2019)
22. Adherence to the Dietary Approaches to Stop Hypertension (Dash) Diet and Risk of Total and Cause-Specific Mortality: Results From the Golestan Cohort Study, International Journal of Epidemiology (2019)
23. Sensitivity of Self-Reported Opioid Use in Case-Control Studies: Healthy Individuals Versus Hospitalized Patients, PLoS ONE (2017)
24. Opium As a Risk Factor for Early-Onset Coronary Artery Disease: Results From the Milano-Iran (Miran) Study, PLoS ONE (2023)
25. Household Fuel Use and Cardiovascular Disease Mortality, Circulation (2016)
26. Hazards of Cigarettes, Smokeless Tobacco and Waterpipe in a Middle Eastern Population: A Cohort Study of 50 000 Individuals From Iran, Tobacco Control (2017)
27. The Persian Cohort: Providing the Evidence Needed for Healthcare Reform, Archives of Iranian Medicine (2017)
28. Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study, American Journal of Epidemiology (2017)
29. Overexpression of Adiponectin Receptors in Opium Users With and Without Cancer, Clinical Pharmacology: Advances and Applications (2020)
30. Prevalence and Determinants of Opioid Use Disorder Among Long-Term Opiate Users in Golestan Cohort Study, BMC Psychiatry (2023)
31. The Combined Effects of Healthy Lifestyle Behaviors on All-Cause Mortality: The Golestan Cohort Study, Archives of Iranian Medicine (2016)
32. Multimorbidity: Epidemiology and Risk Factors in the Golestan Cohort Study, Iran a Cross-Sectional Analysis, Medicine (United States) (2016)
33. Association Between Prediagnostic Risk Factors and Survival After Colorectal Cancer Diagnosis in Golesten Cohort Study, Scientific Reports (2025)
34. Opioid Therapy and Its Side Effects: A Review, Archives of Iranian Medicine (2016)
35. Incidence, Early Case Fatality and Determinants of Stroke in Iran: Golestan Cohort Study, Journal of Stroke and Cerebrovascular Diseases (2022)
36. Causes and Predictors of Premature Death in the Pars Cohort Study, Iran: A Cohort Study, BMC Public Health (2024)
37. Pars Cohort Study of Non-Communicable Diseases in Iran: Protocol and Preliminary Results, International Journal of Public Health (2017)
38. Prevalence and Determinants of Chronic Kidney Disease in Northeast of Iran: Results of the Golestan Cohort Study, PLoS ONE (2017)
39. Opium Use and the Risk of Cataract: A Hospital-Based, Group-Matched, Case–Control Study in Iran, Ophthalmic Epidemiology (2023)
40. Long-Term Opiate Use and Risk of Cardiovascular Mortality: Results From the Golestan Cohort Study, European Journal of Preventive Cardiology (2021)
41. Opium Abuse and Its Problems in Anesthesia Practice: A Review From Bench to Bedside, Journal of Cellular and Molecular Anesthesia (2016)
42. Prevalence and Clinical Outcomes of Common Bile Duct Dilation in Patients Who Use Opium, American Journal of the Medical Sciences (2018)
43. Prospective Epidemiological Research Studies in Iran (The Persian Cohort Study): Rationale, Objectives, and Design, American Journal of Epidemiology (2018)
44. Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study, Cancer Prevention Research (2021)
45. Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases (Polyiran): A Pragmatic, Cluster-Randomised Trial, The Lancet (2019)
46. Smoking Water-Pipe, Opium Use and Prevalence of Heart Disease: A Cross-Sectional Analysis of Baseline Data From the Pars Cohort Study, Southern Iran, Archives of Iranian Medicine (2020)
47. Does Opium Consumption Have Shared Impact on Atherosclerotic Cardiovascular Disease and Cancer?, Archives of Iranian Medicine (2022)
48. Metabolomics Reveals Biomarkers of Opioid Use Disorder, Translational Psychiatry (2021)
49. Mortality and Cancer in Relation to Abo Blood Group Phenotypes in the Golestan Cohort Study, BMC Medicine (2015)
50. Polypill for the Prevention of Cardiovascular Disease (Polyiran): Study Design and Rationale for a Pragmatic Cluster Randomized Controlled Trial, European Journal of Preventive Cardiology (2015)