Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study

Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study Publisher Pubmed

Etemadi A^{1, 2} ; Poustchi H^{2, 3} ; Calafat AM⁴ ; Blount BC⁴ ; De Jesus VR⁴ ; Wang L⁴ ; Pourshams A² ; Shakeri R² ; Inouechoi M¹ ; Shiels MS¹ ; Roshandel G⁵ ; Murphy G¹ ; Sosnoff CS⁴ ; Bhandari D⁴ Show All Authors

Etemadi A^{1, 2}
Poustchi H^{2, 3}
Calafat AM⁴
Blount BC⁴
De Jesus VR⁴
Wang L⁴
Pourshams A²
Shakeri R²
Inouechoi M¹
Shiels MS¹
Roshandel G⁵
Murphy G¹
Sosnoff CS⁴
Bhandari D⁴
Feng J⁴
Xia B⁴
Wang Y⁴
Meng L⁴
Kamangar F⁶
Brennan P⁷
Boffetta P^{8, 9}
Dawsey SM¹
Abnet CC¹
Malekzadeh R^{2, 10}
Freedman ND¹

Show Affiliations

1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
2. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Liver and Pancreaticobilliary Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States
5. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
6. Depart-ment of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, United States
7. International Agency for Research on Cancer, Lyon, France
8. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
9. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
10. Digestive Disease Research Institute, Shariati Hospital, North Kargar Avenue, Tehran, 13135, Iran

Source: Cancer Epidemiology Biomarkers and Prevention Published:2020

Abstract

Background: There is little information on human exposure to carcinogens and other toxicants related to opiate use, alone or in combination with tobacco. Methods: Among male participants of the Golestan Cohort Study in Northeast Iran, we studied 28 never users of either opiates or tobacco, 33 exclusive cigarette smokers, 23 exclusive users of smoked opiates, and 30 opiate users who also smoked cigarettes (dual users; 21 smoked opiates and 9 ingested them). We quantified urinary concentrations of 39 exposure biomarkers, including tobacco alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC), and used decomposition to parse out the share of the biomarker concentrations explained by opiate use and nicotine dose. Results: Dual users had the highest concentrations of all biomarkers, but exclusive cigarette smokers and exclusive opiate users had substantially higher concentrations of PAH and VOC biomarkers than never users of either product. Decomposition analysis showed that opiate use contributed a larger part of the PAH concentrations than nicotine dose, and the sum of 2- and 3-hydroxyphenanthrene (P 2,3-phe) resulted almost completely from opiate use. Concentrations of most VOC biomarkers were explained by both nicotine dose and opiate use. Two acrylamide metabolites, a 1,3-butadiene metabolite and a dimethylformamide metabolite, were more strongly explained by opiate use. Acrylamide metabolites and P 2,3-phe were significantly higher in opiate smokers than opiate eaters; other biomarkers did not vary by the route of opiate intake. Conclusions: Both cigarette smokers and opiate users (by smoking or ingestion) were exposed to many toxicants and carcinogens. Impact: This high exposure, particularly among dual opiate and cigarette users, can have a substantial global public health impact. © 2020 American Association for Cancer Research.

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Experts (# of related papers)

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Reza Malekzadeh (63)

Hossein Poustchi (59)

Style	Citing Format
MLA	Etemadi A, et al.. "Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study." Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 3, 2020, pp. 650-658.
APA	Etemadi A, Poustchi H, Calafat AM, Blount BC, De Jesus VR, Wang L, Pourshams A, Shakeri R, Inouechoi M, Shiels MS, Roshandel G, Murphy G, Sosnoff CS, Bhandari D, Feng J, Xia B, Wang Y, Meng L, Kamangar F, ... Freedman ND (2020). Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study. Cancer Epidemiology Biomarkers and Prevention, 29(3), 650-658.
Chicago	Etemadi A, Poustchi H, Calafat AM, Blount BC, De Jesus VR, Wang L, Pourshams A, et al.. "Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study." Cancer Epidemiology Biomarkers and Prevention 29, no. 3 (2020): 650-658.
Harvard	Etemadi A et al. (2020) 'Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study', Cancer Epidemiology Biomarkers and Prevention, 29(3), pp. 650-658.
Vancouver	Etemadi A, Poustchi H, Calafat AM, Blount BC, De Jesus VR, Wang L, et al.. Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study. Cancer Epidemiology Biomarkers and Prevention. 2020;29(3):650-658.
BibTex	@article{ author = {Etemadi A and Poustchi H and Calafat AM and Blount BC and De Jesus VR and Wang L and Pourshams A and Shakeri R and Inouechoi M and Shiels MS and Roshandel G and Murphy G and Sosnoff CS and Bhandari D and Feng J and Xia B and Wang Y and Meng L and Kamangar F and Brennan P and Boffetta P and Dawsey SM and Abnet CC and Malekzadeh R and Freedman ND}, title = {Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study}, journal = {Cancer Epidemiology Biomarkers and Prevention}, volume = {29}, number = {3}, pages = {650-658}, year = {2020} }
RIS	TY - JOUR AU - Etemadi A AU - Poustchi H AU - Calafat AM AU - Blount BC AU - De Jesus VR AU - Wang L AU - Pourshams A AU - Shakeri R AU - Inouechoi M AU - Shiels MS AU - Roshandel G AU - Murphy G AU - Sosnoff CS AU - Bhandari D AU - Feng J AU - Xia B AU - Wang Y AU - Meng L AU - Kamangar F AU - Brennan P AU - Boffetta P AU - Dawsey SM AU - Abnet CC AU - Malekzadeh R AU - Freedman ND TI - Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study JO - Cancer Epidemiology Biomarkers and Prevention VL - 29 IS - 3 SP - 650 EP - 658 PY - 2020 ER -

Style

Citing Format

MLA

Etemadi A, et al.. "Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study." Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 3, 2020, pp. 650-658.

APA

Etemadi A, Poustchi H, Calafat AM, Blount BC, De Jesus VR, Wang L, Pourshams A, Shakeri R, Inouechoi M, Shiels MS, Roshandel G, Murphy G, Sosnoff CS, Bhandari D, Feng J, Xia B, Wang Y, Meng L, Kamangar F, ... Freedman ND (2020). Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study. Cancer Epidemiology Biomarkers and Prevention, 29(3), 650-658.

Chicago

Etemadi A, Poustchi H, Calafat AM, Blount BC, De Jesus VR, Wang L, Pourshams A, et al.. "Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study." Cancer Epidemiology Biomarkers and Prevention 29, no. 3 (2020): 650-658.

Harvard

Etemadi A et al. (2020) 'Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study', Cancer Epidemiology Biomarkers and Prevention, 29(3), pp. 650-658.

Vancouver

Etemadi A, Poustchi H, Calafat AM, Blount BC, De Jesus VR, Wang L, et al.. Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study. Cancer Epidemiology Biomarkers and Prevention. 2020;29(3):650-658.

BibTex

@article{ author = {Etemadi A and Poustchi H and Calafat AM and Blount BC and De Jesus VR and Wang L and Pourshams A and Shakeri R and Inouechoi M and Shiels MS and Roshandel G and Murphy G and Sosnoff CS and Bhandari D and Feng J and Xia B and Wang Y and Meng L and Kamangar F and Brennan P and Boffetta P and Dawsey SM and Abnet CC and Malekzadeh R and Freedman ND}, title = {Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study}, journal = {Cancer Epidemiology Biomarkers and Prevention}, volume = {29}, number = {3}, pages = {650-658}, year = {2020} }

RIS

TY - JOUR
AU - Etemadi A
AU - Poustchi H
AU - Calafat AM
AU - Blount BC
AU - De Jesus VR
AU - Wang L
AU - Pourshams A
AU - Shakeri R
AU - Inouechoi M
AU - Shiels MS
AU - Roshandel G
AU - Murphy G
AU - Sosnoff CS
AU - Bhandari D
AU - Feng J
AU - Xia B
AU - Wang Y
AU - Meng L
AU - Kamangar F
AU - Brennan P
AU - Boffetta P
AU - Dawsey SM
AU - Abnet CC
AU - Malekzadeh R
AU - Freedman ND
TI - Opiate and Tobacco Use and Exposure to Carcinogens and Toxicants in the Golestan Cohort Study
JO - Cancer Epidemiology Biomarkers and Prevention
VL - 29
IS - 3
SP - 650
EP - 658
PY - 2020
ER -

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Abstract