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A Novel Magnetic Nanocomposite Based on Alginate-Tannic Acid Hydrogel Embedded With Silk Fibroin With Biological Activity and Hyperthermia Application Publisher Pubmed



Eivazzadehkeihan R1 ; Farrokhihajiabad F2 ; Aliabadi HAM3 ; Ziabari EZ4 ; Geshani S2 ; Kashtiaray A2 ; Bani MS5 ; Pishva B2 ; Cohan RA1 ; Maleki A2 ; Mahdavi M6
Authors
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Authors Affiliations
  1. 1. Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  3. 3. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  4. 4. Department of Orthopedic Surgery, Rothman Institute at Thomas Jefferson University, 125 South 9th Street, Suite 1000, Philadelphia, 19107, PA, United States
  5. 5. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2023


Abstract

In the current study, sodium alginate (SA) and tannic acid (TA), in the presence of calcium chloride as a cross-linker, were used to fabricate a nanocomposite scaffold. With the addition of silk fibroin (SF), the strength of the synthesized composite was increased. Fe3O4 magnetic nanoparticles (MNPs) led to the usage of this magnetic nanocomposite in hyperthermia applications. Various properties of this scaffold were investigated by field emission scanning electron microscope (FE-SEM), thermogravimetric analysis (TGA), Fourier-transformed infrared (FT-IR), energy dispersive X-Ray (EDX), Vibrating- sample magnetometer (VSM). A hemolytic assay of this magnetic nanocomposite demonstrated that about 100 % of red blood cells (RBCs) survived at a concentration of 2 mg/ml, proving this scaffold is hemocompatible. Furthermore, an MTT assay was utilized to assess the cytotoxicity of the synthesized magnetic nanocomposite. Finally, the hyperthermia behavior of the fabricated magnetic nanocomposite was evaluated, and the specific absorption rate (SAR) was 73.53 W/g. The proposed nanocomposite is a good candidate for wound dressing applications in future studies. © 2022 Elsevier B.V.
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