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Agar-Tragacanth/Silk Fibroin Hydrogel Containing Zn-Based Mof As a Novel Nanobiocomposite With Biological Activity Publisher Pubmed



Lalebeigi F1 ; Kashtiaray A1 ; Aghamirza Moghim Aliabadi H2 ; Moghadaskhou F1 ; Pajoum Z1 ; Nokandeh SM1 ; Mahdavi M3 ; Eivazzadehkeihan R1 ; Maleki A1
Authors
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Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Medical Biotechnology Department, Biotechnology Research Center (BRC), Pasteur Institute of Iran (IPI), Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Scientific Reports Published:2024


Abstract

In this study, a novel nanobiocomposite consisting of agar (Ag), tragacanth gum (TG), silk fibroin (SF), and MOF-5 was synthesized and extensively investigated by various analytical techniques and basic biological assays for potential biomedical applications. The performed Trypan blue dye exclusion assay indicated that the proliferation percentage of HEK293T cells was 71.19%, while the proliferation of cancer cells (K-562 and MCF-7) was significantly lower, at 10.74% and 3.33%. Furthermore, the Ag-TG hydrogel/SF/MOF-5 nanobiocomposite exhibited significant antimicrobial activity against both E. coli and S. aureus strains, with growth inhibition rates of 76.08% and 69.19% respectively. Additionally, the hemolytic index of fabricated nanobiocomposite was found approximately 19%. These findings suggest that the nanobiocomposite exhibits significant potential for application in cancer therapy and wound healing. © The Author(s) 2024.
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