Spinal Cord Injury: From Micrornas to Exosomal Micrornas Publisher



Xu X¹ ; Liu R¹ ; Li Y¹ ; Zhang C² ; Guo C² ; Zhu J² ; Dong J² ; Ouyang L³ ; Momeni MR⁴ Show Affiliations
Source: Molecular Neurobiology Published:2024

Abstract

Spinal cord injury (SCI) is an unfortunate experience that may generate extensive sensory and motor disabilities due to the destruction and passing of nerve cells. MicroRNAs are small RNA molecules that do not code for proteins but instead serve to regulate protein synthesis by targeting messenger RNA’s expression. After SCI, secondary damage like apoptosis, oxidative stress, inflammation, and autophagy occurs, and differentially expressed microRNAs show a function in these procedures. Almost all animal and plant cells release exosomes, which are sophisticated formations of lipid membranes. These exosomes have the capacity to deliver significant materials, such as proteins, RNAs and lipids, to cells in need, regulating their functions and serving as a way of communication. This new method offers a fresh approach to treating spinal cord injury. Obviously, the exosome has the benefit of conveying the transported material across performing regulatory activities and the blood–brain barrier. Among the exosome cargoes, microRNAs, which modulate their mRNA targets, show considerable promise in the pathogenic diagnosis, process, and therapy of SCI. Herein, we describe the roles of microRNAs in SCI. Furthermore, we emphasize the importance of exosomal microRNAs in this disease. © 2024, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.