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Solubilization of Bosentan Using Ethanol As a Pharmaceutical Cosolvent Publisher



Sajediamin S1 ; Barzegarjalali M2 ; Fathiazarbayjani A3 ; Kebriaeezadeh A4 ; Martinez F5 ; Jouyban A1, 6
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Authors Affiliations
  1. 1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. School of Pharmacy and Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
  4. 4. Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Pharmacoeconomics and Pharmaceutical Administration Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota D.C., Colombia
  6. 6. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, 51664, Iran

Source: Journal of Molecular Liquids Published:2017


Abstract

Solubility of bosentan in ethanol + water mixtures was experimentally determined at five different temperatures (293.2–313.2 K) with respect to the composition of the solvent mixture. Results indicate an ethanol and temperature dependent increase in bosentan solubility. Thermodynamic properties of the solution process were calculated using van't Hoff and Gibbs equations. Generated solubility data were correlated with a number of cosolvency models and the accuracies of the predicted solubilities and model performance were illustrated by mean percentage deviation (MPD). The obtained MPD values for cosolvency models trained using whole data points varied between 5.8 and 46.2%. © 2017 Elsevier B.V.
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