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Measurement and Modelling of the Solubility for Ketoconazole in {Acetonitrile + Water} Mixtures at T = (293.2 to 313.2) K Publisher



Barzegarjalali M1 ; Mazaher Haji Agha E2 ; Mirheydari SN3 ; Adibkia K4 ; Martinez F5 ; Jouyban A6, 7
Authors
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Authors Affiliations
  1. 1. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultadde Ciencias, Universidad Nacional de Colombia – Sede Bogota, Bogota, D.C, Colombia
  6. 6. Pharmaceutical Analysis Research Center, Faculty of Pharmacy, Tabriz University of Medical sciences, Tabriz, Iran
  7. 7. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Physics and Chemistry of Liquids Published:2021


Abstract

The solubilisation behaviour of ketoconazole in the binary mixtures of acetonitrile and water was studied at T = (293.2–313.2) K. The solubility data were represented with seven co-solvency models including Jouyban-Acree, Jouyban-Acree-van’t Hoff, NRTL, Wilson, UNIQUAC, combined nearly ideal binary solvent/Redlich-Kister and modified Wilson models. The computed thermodynamic properties of dissolution suggest that except in neat water, the main contributor to standard Gibbs free energies of dissolution is enthalpy. Furthermore, preferential solvation analysis shows that ketoconazole is preferentially solvated by water in water-rich mixtures and also in acetonitrile-rich mixtures but preferentially solvated by acetonitrile in mixtures of intermediate compositions. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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